Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 11/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9354731 | 1.00 | CYP2C19 (0.45) | CYP2C19CYP3A4CYP2C9TMEM97SIGMAR1 | |
| SCHEMBL9358821 | 0.93 | MEN1 (0.42) | CYP2C19CYP3A4CYP2C9TMEM97SIGMAR1 | |
| SCHEMBL9358829 | 0.93 | MEN1 (0.42) | CYP2C19CYP3A4CYP2C9TMEM97SIGMAR1 | |
| SCHEMBL9358262 | 0.88 | ACE (0.45) | GAA | |
| SCHEMBL9358267 | 0.88 | ACE (0.45) | GAA | |
| SCHEMBL8681953 | 0.86 | MEN1 (0.49) | CYP2C19MEN1KMT2ANPSR1NPC1 | |
| SCHEMBL9354940 | 0.86 | MEN1 (0.49) | CYP2C19MEN1KMT2ANPSR1NPC1 | |
| SCHEMBL2440342 | 0.84 | TMEM97 (0.57) | CYP2C19TMEM97SIGMAR1MEN1KMT2A | |
| SCHEMBL9358190 | 0.81 | L3MBTL1 (0.47) | CYP2C19MEN1KMT2ANPSR1NPC1 | |
| SCHEMBL9354656 | 0.81 | TMEM97 (0.40) | CYP2C19TMEM97SIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0300189-B1 | New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1994-11-02 | — | — | EP | disclosed |
| US-5223489-A | Treatment of ypertension and heart failure | UJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-06-29 | — | — | US | disclosed |
| US-5142048-A | Enzyme inhibitor; carbamoyl group-containing acids | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1992-08-25 | — | — | US | disclosed |
| US-4921855-A | New Histidyl amino acid derivatives, and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-05-01 | — | — | US | disclosed |
| EP-0300189-A2 | New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-01-25 | — | — | EP | disclosed |