Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10884344 | 0.89 | LMNA (0.45) | KDM4EHIF1AALDH1A1HPGDMEN1 | |
| SCHEMBL607092 | 0.80 | KDM4E (0.54) | KDM4EHIF1AALDH1A1HPGDMEN1 | |
| SCHEMBL5320318 | 0.80 | KDM4E (0.54) | KDM4EHIF1AALDH1A1HPGDMEN1 | |
| SCHEMBL15422574 | 0.77 | CLCN2 (0.62) | MEN1KMT2ACLCN2PTGS1ADORA3 | |
| SCHEMBL7276739 | 0.75 | PCNA (0.50) | KDM4EHIF1AALDH1A1HPGDMEN1 | |
| SCHEMBL4926007 | 0.73 | THRB (0.41) | KDM4EHIF1AALDH1A1HPGDMEN1 | |
| Dl-Phenylalanine SCHEMBL28650247 | 0.72 | SLC7A5 (0.71) | KDM4EHIF1AALDH1A1HPGDTSHR | |
| SCHEMBL5287555 | 0.71 | KDM4E (0.53) | KDM4EHIF1AALDH1A1HPGDMEN1 | |
| Dl-Tryptophan SCHEMBL28649899 | 0.71 | KMT2A (0.80) | KDM4EHIF1AALDH1A1MEN1LMNA | |
| Salicylic Acid SCHEMBL935532 | 0.70 | PCNA (0.48) | KDM4EHIF1AALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110165595-A1 | APPARATUS AND METHODS FOR PROCESSING A WHOLE BLOOD SAMPLE | COMERICA BANK | 2011-07-07 | — | — | US | disclosed |
| WO-2011008780-A1 | APPARATUS AND METHODS FOR PROCESSING A WHOLE BLOOD SAMPLE | ACCUMETRICS, INC. (US) | 2011-01-20 | — | — | WO | disclosed |
| EP-1034429-B1 | DEVICE FOR RECEIVING AND PROCESSING A SAMPLE | SENDX MEDICAL INC (US) | 2003-11-05 | — | — | EP | disclosed |
| US-6016712-A | Device for receiving and processing a sample | ACCUMETRICS (US) | 2000-01-25 | — | — | US | disclosed |
| EP-0427534-B1 | Improvement in non-instrumental diagnostic assay distance determination | CHEMTRAK INC (US) | 1995-08-02 | — | — | EP | disclosed |
| US-5260221-A | Quantitative and colorimetric analysis of cholesterol | RAMEL URS A (US) | 1993-11-09 | — | — | US | disclosed |
| US-4959324-A | Sample pad assay initiation device and method of making | CHEMTRAK, INC. (US) | 1990-09-25 | — | — | US | disclosed |