Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCNA | P12004 | 2/20 | 0.48 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.40 |
| ▸ | THRB | P10828 | 8/20 | 0.39 |
| ▸ | THRA | P10827 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10884352 | 0.89 | PCNA (0.59) | PCNASLC7A5THRBTHRALMNA | |
| Dl-Phenylalanine SCHEMBL28650247 | 0.71 | SLC7A5 (0.71) | SLC7A5TSHRABCB11KDM4ECA12 | |
| SCHEMBL379411 | 0.71 | PCNA (0.66) | PCNASLC7A5THRBTHRALMNA | |
| Salicylic Acid SCHEMBL935529 | 0.70 | KDM4E (0.40) | SLC7A5THRBLMNATSHRMEN1 | |
| SCHEMBL2575598 | 0.70 | PCNA (0.64) | PCNASLC7A5THRBTHRALMNA | |
| Hydrochloric Acid SCHEMBL28229787 | 0.70 | PCNA (0.64) | PCNASLC7A5THRBTHRALMNA | |
| SCHEMBL7276734 | 0.70 | PCNA (0.72) | PCNASLC7A5THRBTHRALMNA | |
| Salicylic Acid SCHEMBL7776900 | 0.68 | ALDH1A1 (0.62) | SLC7A5LMNATSHRMEN1KMT2A | |
| Tyrosine SCHEMBL28104369 | 0.68 | SLC7A5 (0.75) | PCNASLC7A5LMNAMEN1ABCB11 | |
| Salicylic Acid SCHEMBL4650853 | 0.68 | ALDH1A1 (0.86) | LMNATSHRMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110165595-A1 | APPARATUS AND METHODS FOR PROCESSING A WHOLE BLOOD SAMPLE | COMERICA BANK | 2011-07-07 | — | — | US | disclosed |
| WO-2011008780-A1 | APPARATUS AND METHODS FOR PROCESSING A WHOLE BLOOD SAMPLE | ACCUMETRICS, INC. (US) | 2011-01-20 | — | — | WO | disclosed |
| EP-1034429-B1 | DEVICE FOR RECEIVING AND PROCESSING A SAMPLE | SENDX MEDICAL INC (US) | 2003-11-05 | — | — | EP | disclosed |
| US-6016712-A | Device for receiving and processing a sample | ACCUMETRICS (US) | 2000-01-25 | — | — | US | disclosed |
| EP-0427534-B1 | Improvement in non-instrumental diagnostic assay distance determination | CHEMTRAK INC (US) | 1995-08-02 | — | — | EP | disclosed |
| US-5260221-A | Quantitative and colorimetric analysis of cholesterol | RAMEL URS A (US) | 1993-11-09 | — | — | US | disclosed |
| US-4959324-A | Sample pad assay initiation device and method of making | CHEMTRAK, INC. (US) | 1990-09-25 | — | — | US | disclosed |