Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL562789 | 0.82 | TDP1 (0.44) | TDP1TP53ALDH1A1GAAMEN1 | |
| SCHEMBL3853744 | 0.81 | TDP1 (0.42) | TDP1TP53ALDH1A1GAAMEN1 | |
| SCHEMBL31189333 | 0.81 | TDP1 (0.42) | TDP1TP53ALDH1A1GAAMEN1 | |
| SCHEMBL15820157 | 0.75 | GAA (0.34) | TDP1TP53ALDH1A1GAATSHR | |
| SCHEMBL17424000 | 0.75 | TDP1 (0.35) | TDP1TP53ALDH1A1GAAMEN1 | |
| SCHEMBL987477 | 0.74 | HTT (0.41) | TDP1ALDH1A1GAATSHRCYP2C9 | |
| SCHEMBL15820162 | 0.74 | GAA (0.33) | ALDH1A1GAATSHRTRPA1 | |
| SCHEMBL9441930 | 0.73 | CYP3A4 (0.32) | TSHR | |
| SCHEMBL27634287 | 0.72 | AMY1A (0.36) | TDP1TP53MEN1KMT2ACYP2C9 | |
| SCHEMBL15759862 | 0.72 | HTT (0.47) | TDP1ALDH1A1GAATSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103370326-B | As the phosphorus derivant of chemokine receptor modulators | ALLERGAN, INC. (US) | 2016-05-11 | — | — | CN | claimed |
| US-5245005-A | Amine end groups, phosphinic acid catalyst | MONSANTO COMPANY (US) | 1993-09-14 | — | — | US | claimed |
| EP-2651957-B1 | PHOSPHOROUS DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN INC (US) | 2015-02-18 | — | — | EP | disclosed |
| EP-2651957-A1 | PHOSPHOROUS DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | Allergan, Inc. (US) | 2013-10-23 | — | — | EP | disclosed |
| US-8518913-B2 | Phosphorous derivatives as chemokine receptor modulators | ALLERGAN, INC. (US) | 2013-08-27 | — | — | US | disclosed |
| US-20120157413-A1 | PHOSPHOROUS DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2012-06-21 | — | — | US | disclosed |
| WO-2012082568-A1 | PHOSPHOROUS DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2012-06-21 | — | — | WO | disclosed |
| EP-0439470-B1 | PROCESS FOR INCREASING THE MOLECULAR WEIGHT OF A POLYAMIDE | DU PONT (US) | 1994-11-02 | — | — | EP | disclosed |
| US-5245005-A | Amine end groups, phosphinic acid catalyst | MONSANTO COMPANY (US) | 1993-09-14 | — | — | US | disclosed |
| EP-0439470-A1 | PROCESS FOR INCREASING THE MOLECULAR WEIGHT OF A POLYAMIDE. | DU PONT (US) | 1991-08-07 | — | — | EP | disclosed |
| US-4966949-A | PHENYLPHOSPHINIC ACID DERIVATIVES; HIGH STRENGTH MATERIAL | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-10-30 | — | — | US | disclosed |
| WO-1990004614-A1 | PROCESS FOR INCREASING THE MOLECULAR WEIGHT OF A POLYAMIDE | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-05-03 | — | — | WO | disclosed |
| US-4359431-A | Preparation of arylphosphinic acids | STAUFFER CHEMICAL COMPANY (US) | 1982-11-16 | — | — | US | disclosed |
| US-4316858-A | Preparation of arylphosphinic acids | STAUFFER CHEMICAL COMPANY (US) | 1982-02-23 | — | — | US | disclosed |
| US-4316859-A | Preparation of arylphosphinic acids | STAUFFER CHEMICAL COMPANY (US) | 1982-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157413-A1 | PHOSPHOROUS DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | CCR5, CXCR3, CXCR2 | TDP1 4467/4885TP53 3572/4885ALDH1A1 4208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.