Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.71 |
| ▸ | RAB9A | P51151 | 4/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.70 |
| ▸ | NPC1 | O15118 | 3/20 | 0.70 |
| ▸ | POLB | P06746 | 2/20 | 0.70 |
| ▸ | RXRA | P19793 | 1/20 | 0.62 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.59 |
| ▸ | RELA | Q04206 | 1/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.56 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | PPARA | Q07869 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29556803 | 1.00 | MRGPRX4 (0.71) | MRGPRX4RAB9ASMN1; SMN2NPC1POLB | |
| SCHEMBL9360159 | 0.96 | MRGPRX4 (0.78) | MRGPRX4RAB9ASMN1; SMN2NPC1POLB | |
| SCHEMBL28336349 | 0.96 | MRGPRX4 (0.69) | MRGPRX4RAB9ASMN1; SMN2NPC1POLB | |
| SCHEMBL22160247 | 0.90 | RAB9A (0.68) | MRGPRX4RAB9ASMN1; SMN2NPC1POLB | |
| SCHEMBL23692893 | 0.89 | RAB9A (0.67) | MRGPRX4RAB9ASMN1; SMN2NPC1POLB | |
| SCHEMBL15680329 | 0.89 | PTPRC (0.59) | MRGPRX4RAB9ASMN1; SMN2NPC1POLB | |
| SCHEMBL12968385 | 0.89 | RAB9A (0.67) | MRGPRX4RAB9ASMN1; SMN2NPC1POLB | |
| SCHEMBL8983023 | 0.88 | SMN1; SMN2 (0.57) | MRGPRX4RAB9ASMN1; SMN2NPC1POLB | |
| SCHEMBL30882515 | 0.87 | RAB9A (0.65) | MRGPRX4RAB9ASMN1; SMN2NPC1POLB | |
| SCHEMBL9356585 | 0.87 | MRGPRX4 (0.58) | MRGPRX4RAB9ASMN1; SMN2NPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4028404-A2 | PENAM DERIVATIVES FOR TREATING BACTERIAL INFECTIONS | Tennor Therapeutics Limited (CN) | 2022-07-20 | — | — | EP | disclosed |
| US-11040987-B2 | Penam derivatives for treating bacterial infections | TENNOR THERAPEUTICS LIMITED (CN) | 2021-06-22 | — | — | US | disclosed |
| WO-2021048613-A2 | PENAM DERIVATIVES FOR TREATING BACTERIAL INFECTIONS | TENNOR THERAPEUTICS LIMITED (CN) | 2021-03-18 | — | — | WO | disclosed |
| US-20210070774-A1 | PENAM DERIVATIVES FOR TREATING BACTERIAL INFECTIONS | TENNOR THERAPEUTICS LIMITED (CN) | 2021-03-11 | — | — | US | disclosed |
| WO-2019070973-A1 | CEPHEM COMPOUNDS WITH LATENT REACTIVE GROUPS | GLADIUS PHARMACEUTICALS CORPORATION (CA) | 2019-04-11 | — | — | WO | disclosed |
| US-20190100534-A1 | Cephem Compounds with Latent Reactive Groups | GLADIUS PHARMACEUTICALS INC (CA) | 2019-04-04 | — | — | US | disclosed |
| EP-2706062-B1 | NOVEL CEPHALOSPORIN DERIVATIVE AND PHARMACEUTICAL COMPOSITION THEREOF | LEGOCHEM BIOSCIENCES INC (KR) | 2018-05-09 | — | — | EP | disclosed |
| US-9630977-B2 | Cephalosporin derivatives and pharmaceutical compositions thereof | LEGOCHEM BIOSCIENCES, INC. (KR) | 2017-04-25 | — | — | US | disclosed |
| EP-2341053-B1 | CEPHALOSPORIN HAVING CATECHOL GROUP | SHIONOGI & CO (JP) | 2016-01-13 | — | — | EP | disclosed |
| EP-2706062-A2 | NOVEL CEPHALOSPORIN DERIVATIVE AND PHARMACEUTICAL COMPOSITION THEREOF | LegoChem Biosciences, Inc. (KR) | 2014-03-12 | — | — | EP | disclosed |
| EP-2341053-A1 | CEPHALOSPORIN HAVING CATECHOL GROUP | Shionogi & Co., Ltd. (JP) | 2011-07-06 | — | — | EP | disclosed |
| EP-0416814-B1 | Antibacterial cephalosporin derivatives | PFIZER (US) | 2002-04-24 | — | — | EP | disclosed |
| US-5504076-A | Cephalosporin compounds | PFIZER INC. (US) | 1996-04-02 | — | — | US | disclosed |
| EP-0416810-B1 | Cephalosporin compounds, process for their preparation, pharmaceutical compositions and intermediates | BEECHAM GROUP PLC (GB) | 1995-02-08 | — | — | EP | disclosed |
| EP-0416410-B1 | Piperaziniocephalosporins | SHIONOGI & CO (JP) | 1994-11-30 | — | — | EP | disclosed |
| US-5275816-A | Cephalosporin derivatives | BEECHAM GROUP P.L.C. (GB) | 1994-01-04 | — | — | US | disclosed |
| US-5143910-A | PIPERAZINIOCEPHALOSPORINS | SHIONOGI & CO., LTD. (JP) | 1992-09-01 | — | — | US | disclosed |
| EP-0416814-A2 | Cephalosporin compounds, process for their preparation, pharmaceutical compositions and intermediates | BEECHAM GROUP PLC (GB) | 1991-03-13 | — | — | EP | disclosed |
| EP-0416410-A1 | Piperaziniocephalosporins | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1991-03-13 | — | — | EP | disclosed |
| EP-0416810-A2 | Cephalosporin compounds, process for their preparation, pharmaceutical compositions and intermediates | Beecham Group p.l.c. (GB) | 1991-03-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210070774-A1 | PENAM DERIVATIVES FOR TREATING BACTERIAL INFECTIONS | BPGM, BLVRB, PREP | MRGPRX4 4240/4885RAB9A 1446/4885SMN1; SMN2 3514/4885 |
| US-11040987-B2 | Penam derivatives for treating bacterial infections | BPGM, BLVRB, PREP | MRGPRX4 4240/4885RAB9A 1446/4885SMN1; SMN2 3514/4885 |
| US-20190100534-A1 | Cephem Compounds with Latent Reactive Groups | PGLS, GNE, COMT | MRGPRX4 4828/4885RAB9A 3322/4885SMN1; SMN2 3428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.