Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR4 | P31391 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.34 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 3/20 | 0.33 |
| ▸ | METAP1 | P53582 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1445867 | 0.87 | PAX8 (0.38) | SSTR4POLBTRIM24TRIM33METAP1 | |
| SCHEMBL27642687 | 0.83 | SSTR4 (0.38) | SSTR4POLBCPB2 | |
| SCHEMBL22507878 | 0.81 | POLB (0.35) | SSTR4POLBMETAP1GPR119RAB9A | |
| SCHEMBL15466723 | 0.79 | SSTR4 (0.35) | SSTR4POLBTRIM24TRIM33 | |
| SCHEMBL20631816 | 0.79 | SSTR4 (0.41) | SSTR4POLBMETAP1RAB9A | |
| SCHEMBL21855448 | 0.78 | L3MBTL1 (0.48) | POLBMETAP1PLCG1 | |
| SCHEMBL29450037 | 0.78 | PLCG1 (0.49) | SSTR4POLBMETAP1GPR119PLCG1 | |
| SCHEMBL15760930 | 0.78 | SSTR4 (0.43) | SSTR4POLBTRIM24TRIM33MMP2 | |
| SCHEMBL6637277 | 0.77 | POLB (0.34) | POLBBACE1GPR119DTYMK | |
| SCHEMBL5834893 | 0.77 | GPR119 (0.38) | SSTR4POLBMETAP1GPR119PAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454250-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2012-05-23 | — | — | EP | disclosed |
| WO-2011008709-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2011-01-20 | — | — | WO | disclosed |