Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9358273 | 1.00 | NPSR1 (0.48) | NPSR1TDP1MEN1KMT2AALDH1A1 | |
| SCHEMBL9358264 | 1.00 | NPSR1 (0.48) | NPSR1TDP1MEN1KMT2AALDH1A1 | |
| SCHEMBL14494485 | 0.83 | SMN1; SMN2 (0.43) | TDP1MEN1KMT2AALDH1A1HTT | |
| SCHEMBL10362582 | 0.83 | NPSR1 (0.50) | NPSR1TDP1MEN1KMT2AHTT | |
| Diphenamide SCHEMBL2026352 | 0.79 | OPRM1 (0.53) | TDP1MEN1KMT2AALDH1A1OPRM1 | |
| Diphenamide SCHEMBL39339 | 0.77 | ALDH1A1 (0.55) | TDP1MEN1KMT2AALDH1A1OPRM1 | |
| Diphenamide SCHEMBL6910614 | 0.77 | ALDH1A1 (0.55) | TDP1MEN1KMT2AALDH1A1OPRM1 | |
| Diphenamide SCHEMBL9202269 | 0.77 | ALDH1A1 (0.55) | TDP1MEN1KMT2AALDH1A1OPRM1 | |
| Diphenamide SCHEMBL23534079 | 0.75 | ALDH1A1 (0.53) | TDP1MEN1KMT2AALDH1A1OPRM1 | |
| Diphenamide SCHEMBL10338756 | 0.75 | ALDH1A1 (0.53) | TDP1MEN1KMT2AALDH1A1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628030-A1 | 2,3,4,5-TETRAHYDRO-1H --3-BENZAZEPINES HAVING ANTI-PSYCHOTIC ACTIVITY, AND SYNTHESIS OF $g(a)-SUBSTITUTED-ARYLACETAMIDES | SCHERING CORPORATION (US) | 1994-12-14 | — | — | EP | disclosed |
| WO-1993016997-A1 | 2,3,4,5-TETRAHYDRO-1H^_-3-BENZAZEPINES HAVING ANTI-PSYCHOTIC ACTIVITY, AND SYNTHESIS OF α-SUBSTITUTED-ARYLACETAMIDES | SCHERING CORPORATION (US) | 1993-09-02 | — | — | WO | disclosed |
| US-5241065-A | Selectively antagonize dopamine D-1 receptors | SCHERING CORPORATION (US) | 1993-08-31 | — | — | US | disclosed |