Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | FNTA | P49354 | 1/20 | 0.48 |
| ▸ | FNTB | P49356 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | CCR6 | P51684 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9358680 | 1.00 | ERN1 (0.59) | ERN1POLBMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL5517865 | 0.88 | ERN1 (0.47) | ERN1POLBMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9551016 | 0.85 | MAPT (0.56) | ERN1MAPTALDH1A1SMN1; SMN2HTT | |
| SCHEMBL9384129 | 0.85 | MAPT (0.56) | ERN1MAPTALDH1A1SMN1; SMN2HTT | |
| SCHEMBL16971054 | 0.85 | ALDH1A1 (0.50) | ERN1POLBMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL14198017 | 0.84 | ERN1 (0.67) | ERN1POLBMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4924517 | 0.83 | ERN1 (0.61) | ERN1POLBMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4019892 | 0.82 | ALDH1A1 (0.51) | POLBMAPTALDH1A1SMN1; SMN2HTT | |
| SCHEMBL4019895 | 0.82 | ALDH1A1 (0.51) | POLBMAPTALDH1A1SMN1; SMN2HTT | |
| SCHEMBL5579245 | 0.81 | ERN1 (0.55) | ERN1POLBMAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0489836-B1 | LIGHT ACTIVATED ACYL-ENZYMES | UNIV DUKE (US) | 1994-12-21 | — | — | EP | disclosed |
| US-5218137-A | Chemical light amplifiers | DUKE UNIVERSITY (US) | 1993-06-08 | — | — | US | disclosed |
| EP-0489836-A4 | LIGHT ACTIVATED ACYL-ENZYMES | — | 1993-05-26 | — | — | EP | disclosed |
| EP-0489836-A1 | LIGHT ACTIVATED ACYL-ENZYMES. | UNIV DUKE (US) | 1992-06-17 | — | — | EP | disclosed |
| US-5114851-A | Serine- or cysteine-containing protease modified by nucleophilic cinnamic acid; photoisomerization; biological switches; medical diagnosis | DUKE UNIVERSITY (US) | 1992-05-19 | — | — | US | disclosed |
| WO-1991003549-A1 | LIGHT ACTIVATED ACYL-ENZYMES | DUKE UNIVERSITY (US) | 1991-03-21 | — | — | WO | disclosed |