Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 14/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 10/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.34 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL935484 | 0.90 | PIK3R1 (0.41) | PIK3CDPIK3CGPIK3R1PIK3CAPIK3CB | |
| SCHEMBL935114 | 0.90 | PIK3CD (0.39) | PIK3CDPIK3CGPIK3R1PIK3CAPIK3CB | |
| SCHEMBL935884 | 0.88 | PIK3R1 (0.44) | PIK3CDPIK3CGPIK3R1PIK3CAPIK3CB | |
| SCHEMBL935687 | 0.83 | PIK3CD (0.38) | PIK3CDPIK3CGPIK3R1PIK3CAPIK3CB | |
| SCHEMBL935671 | 0.81 | PIK3CD (0.51) | PIK3CDPIK3CGPIK3R1PIK3CAPIK3CB | |
| SCHEMBL936855 | 0.81 | PIK3CD (0.58) | PIK3CDPIK3CGPIK3R1PIK3CAPIK3CB | |
| SCHEMBL936853 | 0.81 | PIK3CD (0.58) | PIK3CDPIK3CGPIK3R1PIK3CAPIK3CB | |
| SCHEMBL31594508 | 0.81 | PIK3CD (0.58) | PIK3CDPIK3CGPIK3R1PIK3CAPIK3CB | |
| SCHEMBL31594544 | 0.81 | PIK3CD (0.58) | PIK3CDPIK3CGPIK3R1PIK3CAPIK3CB | |
| SCHEMBL935803 | 0.79 | PIK3R1 (0.46) | PIK3CDPIK3CGPIK3R1PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2456444-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | Intellikine, Inc. (US) | 2012-05-30 | — | — | EP | disclosed |
| WO-2011008302-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | INTELLIKINE, INC. (US) | 2011-01-20 | — | — | WO | disclosed |