Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 15/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MELK | Q14680 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | WDR5 | P61964 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6924025 | 0.91 | PRKD1 (0.55) | PRKD1ALDH1A1L3MBTL1MELKWDR5 | |
| SCHEMBL6922437 | 0.87 | PRKD1 (0.67) | PRKD1ALDH1A1L3MBTL1MELKHTR1A | |
| SCHEMBL1056933 | 0.80 | PRKD1 (0.68) | PRKD1 | |
| SCHEMBL936747 | 0.80 | PRKD1 (0.68) | PRKD1 | |
| SCHEMBL936380 | 0.78 | PRKD1 (0.76) | PRKD1MELK | |
| SCHEMBL6922426 | 0.77 | PRKD1 (0.82) | PRKD1MELKWDR5 | |
| SCHEMBL936340 | 0.77 | PRKD1 (0.83) | PRKD1MELK | |
| SCHEMBL6924016 | 0.74 | PRKD1 (0.67) | PRKD1MELK | |
| SCHEMBL960572 | 0.72 | PRKD1 (0.64) | PRKD1MELKWDR5 | |
| SCHEMBL1083601 | 0.71 | PRKD1 (0.81) | PRKD1MELK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |