Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 13/20 | 0.64 |
| ▸ | WDR5 | P61964 | 2/20 | 0.50 |
| ▸ | MELK | Q14680 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL936826 | 0.90 | PRKD1 (0.79) | PRKD1WDR5MELKKMT2AFLT3 | |
| SCHEMBL6922426 | 0.88 | PRKD1 (0.82) | PRKD1WDR5MELKKMT2A | |
| SCHEMBL936241 | 0.86 | PRKD1 (0.80) | PRKD1WDR5MELKFLT3 | |
| SCHEMBL937642 | 0.86 | PRKD1 (0.77) | PRKD1MELKFLT3 | |
| SCHEMBL936340 | 0.84 | PRKD1 (0.83) | PRKD1MELKPAK1FLT3BCHE | |
| SCHEMBL6924016 | 0.83 | PRKD1 (0.67) | PRKD1MELKFLT3 | |
| SCHEMBL936770 | 0.83 | PRKD1 (0.59) | PRKD1MELKFLT3 | |
| SCHEMBL1056933 | 0.82 | PRKD1 (0.68) | PRKD1 | |
| SCHEMBL936747 | 0.82 | PRKD1 (0.68) | PRKD1 | |
| SCHEMBL17279928 | 0.80 | MAPT (0.54) | PRKD1BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |