Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 15/20 | 0.47 |
| ▸ | MAPT | P10636 | 15/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.47 |
| ▸ | GAA | P10253 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | S100B | P04271 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10153005 | 0.83 | LMNA (0.50) | ALDH1A1MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL2501544 | 0.78 | ALDH1A1 (0.47) | ALDH1A1MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL24227146 | 0.77 | ALDH1A1 (0.42) | ALDH1A1MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL13296552 | 0.75 | ALDH1A1 (0.47) | ALDH1A1MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL5377820 | 0.74 | ALDH1A1 (0.42) | ALDH1A1MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL10020928 | 0.74 | ALDH1A1 (0.49) | ALDH1A1MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL11583222 | 0.72 | ALDH1A1 (0.50) | ALDH1A1MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL3825700 | 0.72 | MAPT (0.48) | ALDH1A1MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL15488863 | 0.72 | ALDH1A1 (0.47) | ALDH1A1MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL11011080 | 0.72 | S100B (0.63) | ALDH1A1MAPTKDM4EGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0489836-B1 | LIGHT ACTIVATED ACYL-ENZYMES | UNIV DUKE (US) | 1994-12-21 | — | — | EP | disclosed |
| US-5114851-A | Serine- or cysteine-containing protease modified by nucleophilic cinnamic acid; photoisomerization; biological switches; medical diagnosis | DUKE UNIVERSITY (US) | 1992-05-19 | — | — | US | disclosed |