SCHEMBL9364332

SCHEMBL9364332

O=C/C(=C/c1ccccc1Cl)c1ccc(F)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.51
NPC1 O15118 2/20 0.51
RAB9A P51151 2/20 0.51
TRPA1 O75762 1/20 0.41
HPGD P15428 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
HTT P42858 2/20 0.41
F2R P25116 1/20 0.40
GAA P10253 1/20 0.40
LMNA P02545 2/20 0.39
ALOX12 P18054 1/20 0.39
ATM Q13315 1/20 0.39
MEN1 O00255 1/20 0.39
HSP90AA1 P07900 1/20 0.39
KMT2A Q03164 1/20 0.39
HSD11B1 P28845 1/20 0.38
ALDH1A1 P00352 3/20 0.36
NQO2 P16083 1/20 0.36
MAOB P27338 1/20 0.35
KDM4E B2RXH2 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3720479 1.00 MAPT (0.51) MAPTNPC1RAB9ATRPA1HPGD
SCHEMBL3720477 1.00 MAPT (0.51) MAPTNPC1RAB9ATRPA1HPGD
SCHEMBL9724966 0.81 ALDH1A1 (0.44) MAPTNPC1RAB9ASMN1; SMN2LMNA
SCHEMBL9682656 0.81 ALDH1A1 (0.44) MAPTNPC1RAB9ASMN1; SMN2LMNA
SCHEMBL9682661 0.81 ALDH1A1 (0.44) MAPTNPC1RAB9ASMN1; SMN2LMNA
SCHEMBL4498407 0.79 NFE2L2 (0.49) MAPTNPC1RAB9AGAAMEN1
SCHEMBL3928356 0.79 NFE2L2 (0.49) MAPTNPC1RAB9AGAAMEN1
SCHEMBL3730157 0.78 NFKB1 (0.44) MAPTNPC1RAB9ALMNAATM
SCHEMBL3730154 0.78 NFKB1 (0.44) MAPTNPC1RAB9ALMNAATM
SCHEMBL4631738 0.78 NFKB1 (0.44) MAPTNPC1RAB9ALMNAATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0352673-B1 1-chloro-1-azolyl-methyloxiranes and fungicides containing them BASF AG (DE) 1994-03-09 EP disclosed
EP-0394843-B1 1- Halovinyl-azoles and fungicides and plant-growth regulators containing them BASF AG (DE) 1993-12-15 EP disclosed
EP-0388871-B1 HERBICIDAL AND PLANT GROWTH REGULATING AZOLYLMETHYLOXIRANES BASF Aktiengesellschaft (DE) 1993-01-13 EP disclosed
US-5098917-A And process for killing fungi BASF AKTIENGESELLSCHAFT (DE) 1992-03-24 US disclosed
US-5084471-A Imidazole and triazole groups BASF AKTIENGESELLSCHAFT (DE) 1992-01-28 US disclosed
US-5028618-A Imidazole oxirane compounds BASF AKTIENGESELLSCHAFT (DE) 1991-07-02 US disclosed
US-5017594-A 1-halo-1-azolylpropenes and -methyloxiranes and fungicides containing these compounds BASF AKTIENGESELLSCHAFT (DE) 1991-05-21 US disclosed
EP-0394843-A1 1- Halovinyl-azoles and fungicides and plant-growth regulators containing them BASF Aktiengesellschaft (DE) 1990-10-31 EP disclosed
US-4963690-A HERBICIDE SYNERGISTS BASF AKTIENGESELLSCHAFT (DE) 1990-10-16 US disclosed
EP-0388871-A1 Herbicidal and plant growth regulating azolylmethyloxiranes BASF Aktiengesellschaft (DE) 1990-09-26 EP disclosed
EP-0352675-A2 Substituted imidazolylmethyloxiranes and substituted imidazolylpropenes, their preparation and fungicides containing them BASF Aktiengesellschaft (DE) 1990-01-31 EP disclosed
EP-0352673-A2 1-chloro-1-azolyl-methyloxiranes and fungicides containing them BASF Aktiengesellschaft (DE) 1990-01-31 EP disclosed