Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 13/20 | 0.59 |
| ▸ | MELK | Q14680 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.49 |
| ▸ | FLT3 | P36888 | 3/20 | 0.48 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1053880 | 0.89 | PRKD1 (0.76) | PRKD1CHEK1FLT3 | |
| SCHEMBL936770 | 0.89 | PRKD1 (0.59) | PRKD1MELKFLT3MAP4K1 | |
| SCHEMBL937642 | 0.86 | PRKD1 (0.77) | PRKD1MELKFLT3MAP4K1 | |
| SCHEMBL937272 | 0.78 | PRKD1 (0.77) | PRKD1MELK | |
| SCHEMBL960572 | 0.77 | PRKD1 (0.64) | PRKD1MELKFLT3 | |
| SCHEMBL936826 | 0.77 | PRKD1 (0.79) | PRKD1MELKFLT3 | |
| SCHEMBL19951717 | 0.76 | MELK (0.69) | PRKD1MELKMAP4K1 | |
| SCHEMBL936241 | 0.76 | PRKD1 (0.80) | PRKD1MELKFLT3 | |
| SCHEMBL6923035 | 0.76 | PRKD1 (0.73) | PRKD1 | |
| SCHEMBL998233 | 0.75 | PRKD1 (0.74) | PRKD1MELKCHEK1FLT3MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |