Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 13/20 | 0.59 |
| ▸ | MELK | Q14680 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 3/20 | 0.46 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.43 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.43 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.42 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.42 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.42 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.42 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.42 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL936444 | 0.89 | PRKD1 (0.59) | PRKD1MELKFLT3MAP4K1 | |
| SCHEMBL937272 | 0.88 | PRKD1 (0.77) | PRKD1MELK | |
| SCHEMBL937642 | 0.86 | PRKD1 (0.77) | PRKD1MELKFLT3MAP4K1 | |
| SCHEMBL6924254 | 0.84 | PRKD1 (0.78) | PRKD1MELKFLT3 | |
| SCHEMBL960572 | 0.83 | PRKD1 (0.64) | PRKD1MELKFLT3 | |
| SCHEMBL6924033 | 0.83 | PRKD1 (0.64) | PRKD1MELKFLT3MAP4K1 | |
| SCHEMBL1053880 | 0.79 | PRKD1 (0.76) | PRKD1FLT3 | |
| SCHEMBL936826 | 0.77 | PRKD1 (0.79) | PRKD1MELKFLT3 | |
| SCHEMBL936241 | 0.76 | PRKD1 (0.80) | PRKD1MELKFLT3 | |
| SCHEMBL6923035 | 0.76 | PRKD1 (0.73) | PRKD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |