Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | GALR2 | O43603 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9365594 | 0.91 | ALDH1A1 (0.57) | GPR35ALDH1A1GAAL3MBTL1KMT2A | |
| SCHEMBL4706310 | 0.87 | ALDH1A1 (0.57) | GPR35ALDH1A1L3MBTL1KMT2AAKR1B1 | |
| SCHEMBL9364473 | 0.86 | LMNA (0.51) | GPR35L3MBTL1KMT2ALMNAMAPT | |
| SCHEMBL9365150 | 0.85 | ALDH1A1 (0.52) | GPR35ALDH1A1GAAL3MBTL1KMT2A | |
| SCHEMBL9364628 | 0.81 | ALDH1A1 (0.50) | GPR35ALDH1A1GAAL3MBTL1KMT2A | |
| SCHEMBL1192392 | 0.80 | HTT (0.62) | ALDH1A1L3MBTL1KMT2ALMNAMAPT | |
| SCHEMBL9364681 | 0.80 | GPR35 (0.55) | GPR35ALDH1A1KMT2AAKR1B1LMNA | |
| SCHEMBL8892134 | 0.79 | GPR35 (0.57) | GPR35ALDH1A1GAAL3MBTL1KMT2A | |
| SCHEMBL9365451 | 0.79 | GPR35 (0.60) | GPR35ALDH1A1GAAL3MBTL1KMT2A | |
| SCHEMBL9363972 | 0.79 | ALDH1A1 (0.64) | GPR35ALDH1A1KMT2AAKR1B1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0377112-B1 | Quinoxaline compounds and their preparation and use | NOVO NORDISK AS (DK) | 1994-08-24 | — | — | EP | disclosed |
| US-5061706-A | 2,3-QUINOXALINEDIONES FOR USE AS NEUROLEPTICS | NOVO NORDISK A/S (DK) | 1991-10-29 | — | — | US | disclosed |
| EP-0377112-A1 | Quinoxaline compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1990-07-11 | — | — | EP | disclosed |