Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | THRA | P10827 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.48 |
| ▸ | ACP1 | P24666 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23167797 | 0.93 | GPR35 (0.63) | GPR35ALDH1A1MAPTNPSR1LMNA | |
| SCHEMBL596433 | 0.85 | ALDH1A1 (0.60) | GPR35ALDH1A1MAPTNPSR1LMNA | |
| SCHEMBL24969427 | 0.84 | MAPT (0.69) | GPR35ALDH1A1MAPTNPSR1HPGD | |
| SCHEMBL11400761 | 0.81 | GPR35 (1.00) | GPR35ALDH1A1MAPTHPGD | |
| SCHEMBL7692960 | 0.79 | GPR35 (0.74) | GPR35MAPTLMNAP2RX1ACP1 | |
| SCHEMBL25780344 | 0.79 | GPR35 (0.57) | GPR35ALDH1A1NPSR1THRBP2RX1 | |
| SCHEMBL9364641 | 0.79 | GPR35 (0.59) | GPR35ALDH1A1MAPTLMNAP2RX1 | |
| SCHEMBL5973284 | 0.78 | GPR35 (0.67) | GPR35ALDH1A1MAPTNPSR1LMNA | |
| SCHEMBL25247718 | 0.77 | GPR35 (0.54) | GPR35ALDH1A1MAPTNPSR1HPGD | |
| SCHEMBL17209749 | 0.77 | GAA (0.49) | GPR35ALDH1A1MAPTNPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0377112-B1 | Quinoxaline compounds and their preparation and use | NOVO NORDISK AS (DK) | 1994-08-24 | — | — | EP | disclosed |
| US-5061706-A | 2,3-QUINOXALINEDIONES FOR USE AS NEUROLEPTICS | NOVO NORDISK A/S (DK) | 1991-10-29 | — | — | US | disclosed |
| EP-0377112-A1 | Quinoxaline compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1990-07-11 | — | — | EP | disclosed |