Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | STAT3 | P40763 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.51 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.51 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HPD | P32754 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9364666 | 0.90 | AKR1B1 (0.53) | KCNMA1KMT2APKMMEN1MAPT | |
| SCHEMBL7976022 | 0.85 | GPR35 (0.57) | KCNMA1KMT2APKMMEN1MAPT | |
| SCHEMBL16739563 | 0.83 | KCNMA1 (0.63) | KCNMA1KMT2APKMMEN1MAPT | |
| SCHEMBL11005634 | 0.83 | KCNMA1 (0.66) | KCNMA1KMT2APKMMEN1MAPT | |
| SCHEMBL8135625 | 0.82 | KCNMA1 (0.55) | KCNMA1KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL5606246 | 0.82 | KCNMA1 (0.64) | KCNMA1KMT2APKMMEN1MAPT | |
| SCHEMBL27672851 | 0.81 | KCNMA1 (0.60) | KCNMA1KMT2APKMMEN1MAPT | |
| SCHEMBL29659895 | 0.81 | KCNMA1 (0.63) | KCNMA1KMT2APKMMEN1MAPT | |
| SCHEMBL22262383 | 0.81 | KCNMA1 (0.63) | KCNMA1KMT2APKMMEN1MAPT | |
| SCHEMBL9364781 | 0.81 | ALDH1A1 (0.59) | KCNMA1KMT2AMAPTALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0377112-B1 | Quinoxaline compounds and their preparation and use | NOVO NORDISK AS (DK) | 1994-08-24 | — | — | EP | disclosed |
| US-5061706-A | 2,3-QUINOXALINEDIONES FOR USE AS NEUROLEPTICS | NOVO NORDISK A/S (DK) | 1991-10-29 | — | — | US | disclosed |
| EP-0377112-A1 | Quinoxaline compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1990-07-11 | — | — | EP | disclosed |