Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 7/20 | 0.60 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | JAK3 | P52333 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 2/20 | 0.38 |
| ▸ | WDR5 | P61964 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6923773 | 0.87 | PRKD1 (0.78) | PRKD1PAK1JAK2WDR5KDM1A | |
| SCHEMBL935479 | 0.76 | PRKD1 (0.79) | PRKD1PAK1NPC1RAB9AWDR5 | |
| SCHEMBL6923791 | 0.76 | PRKD1 (0.95) | PRKD1JAK2JAK3CTSLCTSB | |
| SCHEMBL936515 | 0.75 | PRKD1 (1.00) | PRKD1JAK2JAK3CTSLCTSB | |
| SCHEMBL936000 | 0.72 | PRKD1 (0.78) | PRKD1PAK1JAK2JAK3 | |
| SCHEMBL936340 | 0.72 | PRKD1 (0.83) | PRKD1PAK1 | |
| SCHEMBL961783 | 0.72 | PRKD1 (0.60) | PRKD1NPC1RAB9AWDR5 | |
| SCHEMBL961784 | 0.72 | PRKD1 (0.60) | PRKD1NPC1RAB9AWDR5 | |
| SCHEMBL6923549 | 0.71 | PRKD1 (0.54) | PRKD1PAK1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL958407 | 0.71 | PRKD1 (0.72) | PRKD1JAK2JAK3CTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |