Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4138153 | 0.82 | ALDH1A1 (0.46) | MEN1MAPTKMT2AALDH1A1TDP1 | |
| SCHEMBL11163249 | 0.82 | ALDH1A1 (0.47) | EGFRMEN1MAPTKMT2AGAA | |
| SCHEMBL30334982 | 0.80 | ALDH1A1 (0.45) | EGFRMEN1MAPTKMT2AGAA | |
| SCHEMBL9365204 | 0.79 | HTT (0.40) | MEN1MAPTKMT2AALDH1A1TDP1 | |
| SCHEMBL14993728 | 0.79 | TDP1 (0.42) | SMN1; SMN2EGFRMAPTALDH1A1TDP1 | |
| SCHEMBL522262 | 0.79 | HTT (0.64) | MEN1MAPTKMT2AALDH1A1TDP1 | |
| SCHEMBL26353609 | 0.79 | ALDH1A1 (0.47) | SMN1; SMN2MEN1MAPTKMT2AGAA | |
| SCHEMBL6665406 | 0.79 | VCAM1 (0.47) | EGFRMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL24825614 | 0.78 | GPR35 (0.43) | EGFRMEN1MAPTKMT2AGAA | |
| SCHEMBL13835715 | 0.78 | ALDH1A1 (0.43) | MEN1MAPTKMT2AALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0377112-B1 | Quinoxaline compounds and their preparation and use | NOVO NORDISK AS (DK) | 1994-08-24 | — | — | EP | disclosed |
| US-5061706-A | 2,3-QUINOXALINEDIONES FOR USE AS NEUROLEPTICS | NOVO NORDISK A/S (DK) | 1991-10-29 | — | — | US | disclosed |
| EP-0377112-A1 | Quinoxaline compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1990-07-11 | — | — | EP | disclosed |