Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9364955 | 1.00 | SLC6A3 (0.45) | SLC6A3SLC6A2KCNH2DRD3CHRM2 | |
| SCHEMBL31080235 | 1.00 | SLC6A3 (0.45) | SLC6A3SLC6A2KCNH2DRD3CHRM2 | |
| SCHEMBL1177495 | 0.79 | SLC6A3 (0.53) | SLC6A3SLC6A2KCNH2DRD3CHRM2 | |
| SCHEMBL1177493 | 0.79 | SLC6A3 (0.53) | SLC6A3SLC6A2KCNH2DRD3CHRM2 | |
| SCHEMBL20772699 | 0.79 | CDK2 (0.39) | KCNH2CYP1A2HSD17B10MEN1CYP3A4 | |
| SCHEMBL23012711 | 0.79 | MET (0.39) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL9965911 | 0.78 | CHRNB2 (0.33) | KCNH2CYP1A2HSD17B10MEN1CYP3A4 | |
| SCHEMBL31080558 | 0.78 | CHRM2 (0.39) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL31080112 | 0.78 | CHRM2 (0.39) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL31080402 | 0.78 | CHRM2 (0.48) | KCNH2CHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0306148-B1 | Azabicyclic ethers | WYETH JOHN & BROTHER LTD (GB) | 1994-01-12 | — | — | EP | claimed |
| US-5082843-A | PYRAZINYL AND PYRIDAZINYL ETHERS | JOHN WYETH AND BROTHER LIMITED (GB) | 1992-01-21 | — | — | US | claimed |
| EP-0306148-B1 | Azabicyclic ethers | WYETH JOHN & BROTHER LTD (GB) | 1994-01-12 | — | — | EP | disclosed |
| US-5082843-A | PYRAZINYL AND PYRIDAZINYL ETHERS | JOHN WYETH AND BROTHER LIMITED (GB) | 1992-01-21 | — | — | US | disclosed |
| US-4929625-A | Ethers | JOHN WYETH AND BROTHERS LIMITED (GB) | 1990-05-29 | — | — | US | disclosed |