Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 4-Methoxycinnamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.73 |
| ▸ | ATM | Q13315 | 1/20 | 0.73 |
| ▸ | GSK3B | P49841 | 2/20 | 0.62 |
| ▸ | F3 | P13726 | 2/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | BACE1 | P56817 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 4-Methoxycinnamic Acid SCHEMBL936503 | 1.00 | THRB (0.73) | THRBATMGSK3BF3HDAC3 | |
| 4-Methoxycinnamic Acid SCHEMBL9725991 | 0.92 | THRB (0.62) | THRBATMGSK3BF3HDAC3 | |
| 4-Methoxycinnamic Acid SCHEMBL29659712 | 0.91 | THRB (0.61) | THRBATMGSK3BF3HDAC3 | |
| 4-Methoxycinnamic Acid SCHEMBL28249256 | 0.86 | THRB (0.86) | THRBATMGSK3BF3HDAC3 | |
| Diethanolamine SCHEMBL5054345 | 0.86 | KDM4E (0.57) | THRBATMRAB9ANPC1SMN1; SMN2 | |
| 4-Methoxycinnamic Acid SCHEMBL58699 | 0.86 | THRB (1.00) | THRBATMGSK3BF3HDAC3 | |
| 4-Methoxycinnamic Acid SCHEMBL58700 | 0.86 | THRB (1.00) | THRBATMGSK3BF3HDAC3 | |
| Diethanolamine SCHEMBL5054343 | 0.86 | KDM4E (0.57) | THRBATMRAB9ANPC1SMN1; SMN2 | |
| 4-Methoxycinnamic Acid SCHEMBL12473722 | 0.86 | THRB (1.00) | THRBATMGSK3BF3HDAC3 | |
| 4-Methoxycinnamic Acid SCHEMBL9345223 | 0.85 | THRB (0.78) | THRBATMGSK3BF3HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1727 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260130837-A1 | SPF BOOSTER AND SUNCARE FORMULATIONS INCLUDING SAME | DOW SILICONES CORP (US) | 2026-05-14 | — | — | US | claimed |
| WO-2026089856-A1 | METHOD OF PREPARING AND USING A SKIN CARE FORMULATION | DOW SILICONES CORPORATION (US) | 2026-04-30 | — | — | WO | claimed |
| WO-2026089857-A1 | METHOD OF PREPARING AND USING A SKIN CARE COMPOSITION | DOW SILICONES CORPORATION (US) | 2026-04-30 | — | — | WO | claimed |
| EP-4061326-B1 | PERSONAL CARE COMPOSITION COMPRISING A MULTISTAGE POLYMER | DOW GLOBAL TECHNOLOGIES LLC (US) | 2026-02-25 | — | — | EP | claimed |
| US-12514802-B2 | Polymer/hydrophobic ester oil blend | DOW SILICONES CORPORATION (US) | 2026-01-06 | — | — | US | claimed |
| WO-2025216872-A1 | UV ABSORBING COSMETIC COMPOSITIONS THAT EXHIBIT SUN PROTECTION FACTOR BOOSTING IN THE PRESENCE OF BIODEGRADABLE CELLULOSE ESTER MICROBEADS | EASTMAN CHEMICAL COMPANY (US) | 2025-10-16 | — | — | WO | claimed |
| EP-4093514-B1 | AQUEOUS SUNCASE FORMULATION BASED ON SULFATED A CRYSTALLINE CELLULOSE SPF BOOSTER | DOW GLOBAL TECHNOLOGIES LLC (US) | 2025-08-06 | — | — | EP | claimed |
| EP-4590260-A1 | SPF BOOSTER AND SUNCARE FORMULATIONS INCLUDING SAME | Dow Silicones Corporation (US) | 2025-07-30 | — | — | EP | claimed |
| EP-4590261-A1 | SUN CARE FORMULATION | Rohm and Haas Company (US) | 2025-07-30 | — | — | EP | claimed |
| US-12370134-B2 | Personal care formulation | DOW GLOBAL TECHNOLOGIES LLC (US) | 2025-07-29 | — | — | US | claimed |
| WO-1991017740-A1 | PREVENTION OR TREATMENT OF SUNBURN USING THE S(+) ISOMER OF FLURBIPROFEN | ANALGESIC ASSOCIATES (US) | 1991-11-28 | — | — | WO | claimed |
| EP-0261812-B1 | COSMETIC COMPOSITION | UNILEVER PLC (GB) | 1991-08-14 | — | — | EP | claimed |
| EP-0358528-A2 | Cosmetic composition | UNILEVER PLC (GB) | 1990-03-14 | — | — | EP | claimed |
| EP-0261812-A1 | Cosmetic composition | UNILEVER PLC (GB) | 1988-03-30 | — | — | EP | claimed |
| US-4731242-A | Waterproof sunscreen compositions | PALINCZAR VICTOR (US) | 1988-03-15 | — | — | US | claimed |
| US-4710371-A | BUTENE POLYMER AND ULTRAVIOLET RADIATION ABSORBER | PALINCZAR VICTOR (US) | 1987-12-01 | — | — | US | claimed |
| US-4699779-A | Waterproof sunscreen compositions | PALINCZAR VICTOR | 1987-10-13 | — | — | US | claimed |
| US-4686099-A | Aerosol waterproof sunscreen compositions | CHESEBROUGH-POND'S INC. | 1987-08-11 | — | — | US | claimed |
| US-4671956-A | STABILITY; SIDE EFFECT REDUCTION | L'OREAL (FR) | 1987-06-09 | — | — | US | claimed |
| US-4671955-A | ETHYL HYDROXYETHYL CELLULOSE AND AN ULTRAVIOLET RADIATION ABSORBER | PALINCZAR VICTOR | 1987-06-09 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12370134-B2 | Personal care formulation | F12, C1R, MC1R | THRB 1650/4885ATM 633/4885GSK3B 4603/4885 |
| US-20260130837-A1 | SPF BOOSTER AND SUNCARE FORMULATIONS INCLUDING SAME | SDC1, DSC1, SORD | THRB 3900/4885ATM 191/4885GSK3B 2294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.