Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 8/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | FPR1 | P21462 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9370537 | 0.85 | POLB (0.61) | PTGS1PTGS2POLBLMNANPC1 | |
| SCHEMBL9367490 | 0.85 | POLB (0.65) | PTGS1PTGS2POLBLMNANPC1 | |
| SCHEMBL9369861 | 0.81 | POLB (0.53) | PTGS1PTGS2POLBLMNANPC1 | |
| SCHEMBL9366423 | 0.81 | PTGS1 (0.54) | PTGS1PTGS2KIF11BACE1GLO1 | |
| SCHEMBL26135653 | 0.81 | PTGS1 (0.56) | PTGS1PTGS2KIF11BACE1GLO1 | |
| SCHEMBL9367013 | 0.79 | POLB (0.50) | PTGS1PTGS2POLBLMNANPC1 | |
| SCHEMBL14516374 | 0.79 | PTGS1 (0.78) | PTGS1PTGS2KIF11BACE1FPR1 | |
| SCHEMBL9372003 | 0.78 | PTGS1 (0.61) | PTGS1PTGS2POLBRECQLNPC1 | |
| SCHEMBL14516249 | 0.76 | PTGS1 (0.73) | PTGS1PTGS2KIF11BACE1 | |
| SCHEMBL9371990 | 0.76 | POLB (0.47) | PTGS1PTGS2POLBLMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409163-B1 | Novel cyclic vinylogous N-hydroxy-N-methylureas useful as 5-lipoxygenase inhibitors | MERRELL DOW PHARMA (US) | 1994-12-21 | — | — | EP | disclosed |