Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9370537 | 0.97 | POLB (0.61) | POLBLMNAPTGS1PTGS2RAB9A | |
| SCHEMBL9369861 | 0.89 | POLB (0.53) | POLBLMNAPTGS1PTGS2RAB9A | |
| SCHEMBL9367013 | 0.86 | POLB (0.50) | POLBLMNAPTGS1PTGS2RAB9A | |
| SCHEMBL9366255 | 0.85 | PTGS1 (0.56) | POLBLMNAPTGS1PTGS2RAB9A | |
| SCHEMBL9372003 | 0.85 | PTGS1 (0.61) | POLBPTGS1PTGS2RAB9ANPC1 | |
| SCHEMBL9371990 | 0.83 | POLB (0.47) | POLBLMNAPTGS1PTGS2RAB9A | |
| SCHEMBL9367737 | 0.81 | GSTP1 (0.48) | POLBLMNAPTGS1PTGS2RAB9A | |
| SCHEMBL14516372 | 0.80 | PTGS1 (0.73) | POLBPTGS1PTGS2RAB9ANPC1 | |
| SCHEMBL9371933 | 0.78 | POLB (0.42) | POLBLMNAPTGS1PTGS2ALDH1A1 | |
| SCHEMBL9371813 | 0.77 | HSP90AA1 (0.46) | POLBLMNAPTGS1PTGS2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409163-B1 | Novel cyclic vinylogous N-hydroxy-N-methylureas useful as 5-lipoxygenase inhibitors | MERRELL DOW PHARMA (US) | 1994-12-21 | — | — | EP | disclosed |
| US-5109010-A | Lipoxygenase inhibitor; antiasthmic, antiarthritic agent | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-04-28 | — | — | US | disclosed |
| US-5026861-A | Antiarthritic asthma agent, lipoxygenase inhibitors | MERRELL DOW PHARMACEUTICALS (US) | 1991-06-25 | — | — | US | disclosed |
| EP-0409163-A2 | Novel cyclic vinylogous N-hydroxy-N-methylureas useful as 5-lipoxygenase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-01-23 | — | — | EP | disclosed |