Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9367490 | 0.97 | POLB (0.65) | POLBPTGS1PTGS2LMNAALDH1A1 | |
| SCHEMBL9369861 | 0.89 | POLB (0.53) | POLBPTGS1PTGS2LMNAALDH1A1 | |
| SCHEMBL9367013 | 0.86 | POLB (0.50) | POLBPTGS1PTGS2LMNAALDH1A1 | |
| SCHEMBL9366255 | 0.85 | PTGS1 (0.56) | POLBPTGS1PTGS2LMNANPC1 | |
| SCHEMBL9372003 | 0.85 | PTGS1 (0.61) | POLBPTGS1PTGS2ALDH1A1MAPT | |
| SCHEMBL9371990 | 0.83 | POLB (0.47) | POLBPTGS1PTGS2LMNAALDH1A1 | |
| SCHEMBL9367737 | 0.81 | GSTP1 (0.48) | POLBPTGS1PTGS2LMNAMAPT | |
| SCHEMBL9371933 | 0.78 | POLB (0.42) | POLBPTGS1PTGS2LMNAALDH1A1 | |
| SCHEMBL14516372 | 0.77 | PTGS1 (0.73) | POLBPTGS1PTGS2NPC1RAB9A | |
| SCHEMBL9371813 | 0.77 | HSP90AA1 (0.46) | POLBPTGS1PTGS2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409163-B1 | Novel cyclic vinylogous N-hydroxy-N-methylureas useful as 5-lipoxygenase inhibitors | MERRELL DOW PHARMA (US) | 1994-12-21 | — | — | EP | disclosed |