Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL115527 | 0.87 | LMNA (0.47) | LMNAADRB2ADRB1ADRB3DNM1 | |
| SCHEMBL30539136 | 0.85 | LMNA (0.45) | LMNAADRB2ADRB1ADRB3DNM1 | |
| SCHEMBL161314 | 0.84 | LMNA (0.42) | LMNA | |
| SCHEMBL6376885 | 0.82 | LMNA (0.43) | LMNAADRB2ADRB1ADRB3DNM1 | |
| SCHEMBL27859745 | 0.82 | DNM1 (0.48) | LMNAADRB2ADRB1ADRB3DNM1 | |
| SCHEMBL1426655 | 0.80 | LMNA (0.63) | LMNAADRB2ADRB1ADRB3DNM1 | |
| SCHEMBL8766929 | 0.80 | LMNA (0.41) | LMNAADRB2ADRB1ADRB3DNM1 | |
| SCHEMBL4842907 | 0.80 | — | — | |
| SCHEMBL28557811 | 0.79 | DNM1 (0.50) | LMNADNM1TSHRALDH1A1 | |
| SCHEMBL6122979 | 0.77 | ADRB2 (0.39) | LMNAADRB2ADRB1ADRB3DNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0594588-A1 | CYCLOALKYL-SUBSTITUTED GLUTARAMIDE ANTIHYPERTENSIVE AGENTS | Pfizer Limited (GB) | 1994-05-04 | — | — | EP | disclosed |