Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CALM1 | P0DP23 | 2/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10372347 | 0.91 | CALM1 (0.47) | CALM1ALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL5679284 | 0.87 | IDH1 (0.44) | ALDH1A1LMNAHPGDSMN1; SMN2MEN1 | |
| SCHEMBL890366 | 0.86 | PTGS2 (0.50) | IGF1RALOX15CALM1ESR1CYP19A1 | |
| SCHEMBL18917599 | 0.86 | IGF1R (0.40) | IGF1RALOX15ESR1CYP19A1ESR2 | |
| SCHEMBL7028563 | 0.85 | IGF1R (0.42) | IGF1RALOX15ESR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8084853 | 0.85 | GAA (0.38) | ESR2ALDH1A1LMNAHPGDMEN1 | |
| SCHEMBL5718608 | 0.85 | GAA (0.38) | ESR2ALDH1A1LMNAHPGDMEN1 | |
| SCHEMBL5718660 | 0.85 | GAA (0.38) | ESR2ALDH1A1LMNAHPGDMEN1 | |
| SCHEMBL8082255 | 0.85 | GAA (0.38) | ESR2ALDH1A1LMNAHPGDMEN1 | |
| SCHEMBL8072193 | 0.85 | GAA (0.38) | ESR2ALDH1A1LMNAHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0604529-A1 | PYRIDINE COMPOUNDS FOR TREATING LEUKOTRIENE-RELATED DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1994-07-06 | — | — | EP | disclosed |
| WO-1993006085-A1 | PYRIDINE COMPOUNDS FOR TREATING LEUKOTRIENE-RELATED DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-01 | — | — | WO | disclosed |