Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 12/20 | 1.00 |
| ▸ | PRKACA | P17612 | 3/20 | 0.76 |
| ▸ | PRKACG | P22612 | 3/20 | 0.76 |
| ▸ | PRKACB | P22694 | 3/20 | 0.76 |
| ▸ | NOX4 | Q9NPH5 | 5/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.51 |
| ▸ | BCL2 | P10415 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7983491 | 0.87 | SRC (1.00) | SRCPRKACAPRKACGPRKACBNOX4 | |
| SCHEMBL7981059 | 0.87 | SRC (1.00) | SRCPRKACAPRKACGPRKACBNOX4 | |
| SCHEMBL7980552 | 0.83 | SRC (1.00) | SRCPRKACAPRKACGPRKACBNOX4 | |
| SCHEMBL7983612 | 0.82 | SRC (0.70) | SRCPRKACAPRKACGPRKACBNOX4 | |
| SCHEMBL7983999 | 0.82 | SRC (1.00) | SRCPRKACAPRKACGPRKACBNOX4 | |
| SCHEMBL7981707 | 0.80 | SRC (1.00) | SRCPRKACAPRKACGPRKACBNOX4 | |
| SCHEMBL7984057 | 0.78 | SRC (1.00) | SRCPRKACAPRKACGPRKACBNOX4 | |
| SCHEMBL7970086 | 0.78 | SRC (0.63) | SRCPRKACAPRKACGPRKACBALDH1A1 | |
| SCHEMBL22203802 | 0.77 | SRC (0.62) | SRCMEN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL7981060 | 0.76 | NOX4 (1.00) | SRCPRKACAPRKACGPRKACBNOX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |