Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | PRKACA | P17612 | 1/20 | 0.50 |
| ▸ | PRKACG | P22612 | 1/20 | 0.50 |
| ▸ | PRKACB | P22694 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | EDNRB | P24530 | 1/20 | 0.49 |
| ▸ | EDNRA | P25101 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9370571 | 0.88 | SRC (0.57) | SRCTSHRALDH1A1MAPTKDM4E | |
| SCHEMBL7970466 | 0.88 | SRC (0.69) | SRCTSHRALDH1A1MAPTKDM4E | |
| SCHEMBL7983884 | 0.84 | SRC (0.67) | SRCTSHRALDH1A1MAPTKDM4E | |
| SCHEMBL7984333 | 0.84 | MAPT (0.53) | SRCTSHRALDH1A1MAPTKDM4E | |
| SCHEMBL7980591 | 0.83 | TSHR (0.52) | SRCTSHRALDH1A1MAPTKDM4E | |
| SCHEMBL7981572 | 0.82 | NOX4 (0.68) | SRCTSHRALDH1A1KDM4EPRKACA | |
| SCHEMBL7980611 | 0.82 | SRC (0.60) | SRCTSHRALDH1A1MAPTKDM4E | |
| SCHEMBL7970469 | 0.78 | NOX4 (0.71) | SRCTSHRALDH1A1MAPTPRKACA | |
| SCHEMBL9367302 | 0.78 | SRC (1.00) | SRCALDH1A1MAPTKDM4EPRKACA | |
| SCHEMBL7970968 | 0.77 | TSHR (0.47) | SRCTSHRALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |