Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 11/20 | 0.92 |
| ▸ | HTR7 | P34969 | 6/20 | 0.92 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.92 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.92 |
| ▸ | MPO | P05164 | 1/20 | 0.68 |
| ▸ | HTR6 | P50406 | 1/20 | 0.68 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6589735 | 0.92 | HTR1A (0.89) | HTR1AHTR7KCNH2SLC6A4MPO | |
| SCHEMBL6594438 | 0.91 | HTR1A (0.86) | HTR1AHTR7KCNH2SLC6A4MPO | |
| SCHEMBL9367741 | 0.90 | HTR1A (0.74) | HTR1AHTR7KCNH2SLC6A4HTR6 | |
| SCHEMBL7461356 | 0.89 | HTR1A (0.76) | HTR1AHTR7KCNH2SLC6A4MPO | |
| SCHEMBL6589839 | 0.87 | HTR1A (0.80) | HTR1AHTR7KCNH2SLC6A4MPO | |
| SCHEMBL8539217 | 0.87 | KCNH2 (0.73) | HTR1AHTR7KCNH2SLC6A4HTR6 | |
| SCHEMBL11820831 | 0.86 | HTR1A (0.79) | HTR1AHTR7KCNH2SLC6A4HTR6 | |
| SCHEMBL7466625 | 0.86 | HTR1A (0.73) | HTR1AHTR7KCNH2SLC6A4 | |
| SCHEMBL9266136 | 0.86 | HTR1A (0.69) | HTR1AHTR7KCNH2SLC6A4ADRA1A | |
| SCHEMBL8543460 | 0.85 | ADRA2A (0.73) | HTR1AHTR7KCNH2SLC6A4ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376607-B1 | Piperazinyl derivatives | LUNDBECK & CO AS H (DK) | 1994-03-02 | — | — | EP | disclosed |