Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.69 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.69 |
| ▸ | HTR7 | P34969 | 1/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.69 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.62 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.62 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.62 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.62 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9281902 | 0.93 | HTR1A (0.61) | HTR1ASLC6A4HTR7KCNH2ADRA2A | |
| SCHEMBL9261633 | 0.92 | SLC6A4 (0.68) | HTR1ASLC6A4HTR7KCNH2ADRA2A | |
| SCHEMBL8543460 | 0.92 | ADRA2A (0.73) | HTR1ASLC6A4HTR7KCNH2ADRA2A | |
| SCHEMBL9699224 | 0.90 | ADRA2A (0.66) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL9698938 | 0.88 | HTR1A (0.67) | HTR1ASLC6A4HTR7KCNH2ADRA2A | |
| SCHEMBL9617001 | 0.87 | KDM4E (0.61) | HTR1ASLC6A4HTR7KCNH2ADRA1A | |
| SCHEMBL9256046 | 0.87 | ADRA2A (0.62) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL9368593 | 0.86 | HTR1A (0.92) | HTR1ASLC6A4HTR7KCNH2ADRA1A | |
| SCHEMBL9697906 | 0.86 | HTR1A (0.67) | HTR1ASLC6A4HTR7KCNH2ADRA2A | |
| SCHEMBL8537712 | 0.86 | MPO (0.67) | SLC6A4HTR7ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5418237-A | Indole derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-05-23 | — | — | US | disclosed |