Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.65 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | CNR2 | P34972 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | KDM1A | O60341 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CFTR | P13569 | 2/20 | 0.51 |
| ▸ | FAAH | O00519 | 1/20 | 0.51 |
| ▸ | RORC | P51449 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9374874 | 0.90 | ABL1 (0.64) | ABL1GSTO1MEN1KMT2AMAPT | |
| SCHEMBL9706553 | 0.90 | ABL1 (0.58) | ABL1GSTO1MEN1KMT2AMAPT | |
| SCHEMBL9374616 | 0.89 | LMNA (0.66) | ABL1GSTO1MEN1KMT2AMAPT | |
| SCHEMBL9371260 | 0.86 | HDAC3 (0.56) | ABL1CNR2NPC1ROCK2ROCK1 | |
| SCHEMBL9378540 | 0.86 | MEN1 (0.59) | ABL1MEN1KMT2AMAPTCNR2 | |
| SCHEMBL9370967 | 0.86 | ABL1 (0.62) | ABL1GSTO1MEN1KMT2AMAPT | |
| SCHEMBL9371263 | 0.86 | NPC1 (0.68) | GSTO1MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL9373501 | 0.85 | ABL1 (0.65) | ABL1MEN1KMT2AMAPTRECQL | |
| SCHEMBL9370668 | 0.84 | ALDH1A1 (0.69) | MEN1KMT2AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL9371376 | 0.83 | KMT2A (0.64) | MEN1KMT2AMAPTALDH1A1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0589985-A1 | 2-AMINO-4-ARYL-THIAZOLES WITH ANTIASTHMATIC AND ANTI-INFLAMMATORY ACTIVITIES ON THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1994-04-06 | — | — | EP | disclosed |
| WO-1993000342-A1 | 2-AMINO-4-ARYL-THIAZOLES WITH ANTIASTHMATIC AND ANTI-INFLAMMATORY ACTIVITIES ON THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1993-01-07 | — | — | WO | disclosed |
| EP-0519449-A1 | 2-Amino-4-aryl thiazoles with antiasthmatic and antiinflammatory activities on the respiratory tract | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-12-23 | — | — | EP | disclosed |