Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.59 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | CNR2 | P34972 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 2/20 | 0.54 |
| ▸ | MAOB | P27338 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9371121 | 0.90 | ROCK1 (0.62) | ABL1MAPTLMNASMN1; SMN2ALOX12 | |
| SCHEMBL9371629 | 0.89 | ABL1 (0.61) | ABL1MAPTLMNASMN1; SMN2ALOX12 | |
| SCHEMBL9376664 | 0.88 | ABL1 (0.63) | ABL1MAPTLMNASMN1; SMN2ALOX12 | |
| SCHEMBL9373265 | 0.88 | LMNA (0.79) | ABL1MAPTLMNASMN1; SMN2ALOX12 | |
| SCHEMBL9370348 | 0.88 | LMNA (0.61) | MAPTLMNASMN1; SMN2MAPK1RAB9A | |
| SCHEMBL9370971 | 0.88 | LMNA (0.61) | LMNAMAPK1HTTRAB9AROCK1 | |
| SCHEMBL9371263 | 0.87 | NPC1 (0.68) | MAPTLMNASMN1; SMN2HTTRAB9A | |
| SCHEMBL9373501 | 0.87 | ABL1 (0.65) | ABL1MAPTLMNARAB9AROCK1 | |
| SCHEMBL9370428 | 0.86 | ABL1 (0.65) | ABL1MAPTLMNASMN1; SMN2RAB9A | |
| SCHEMBL9370859 | 0.86 | NPC1 (0.57) | MAPTLMNAHTTRAB9AROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0589985-A1 | 2-AMINO-4-ARYL-THIAZOLES WITH ANTIASTHMATIC AND ANTI-INFLAMMATORY ACTIVITIES ON THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1994-04-06 | — | — | EP | disclosed |
| WO-1993000342-A1 | 2-AMINO-4-ARYL-THIAZOLES WITH ANTIASTHMATIC AND ANTI-INFLAMMATORY ACTIVITIES ON THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1993-01-07 | — | — | WO | disclosed |
| EP-0519449-A1 | 2-Amino-4-aryl thiazoles with antiasthmatic and antiinflammatory activities on the respiratory tract | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-12-23 | — | — | EP | disclosed |