Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 13/20 | 0.50 |
| ▸ | MAOA | P21397 | 5/20 | 0.47 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PTPRB | P23467 | 1/20 | 0.44 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9370232 | 0.86 | MAOB (0.50) | MAOBMAOAHMOX1AR | |
| SCHEMBL29992952 | 0.80 | CYP4F2 (0.53) | MAOBMAOA | |
| SCHEMBL1932252 | 0.80 | CYP4F2 (0.53) | MAOBMAOA | |
| SCHEMBL21645942 | 0.79 | ALDH1A1 (0.42) | — | |
| SCHEMBL11426612 | 0.78 | MAOB (0.67) | MAOBHMOX1PTPN2PTPN1PTPRB | |
| SCHEMBL508697 | 0.77 | MAOB (0.70) | MAOBHMOX1PTPN2PTPN1PTPRB | |
| SCHEMBL5515224 | 0.77 | MAOB (0.70) | MAOBHMOX1PTPN2PTPN1PTPRB | |
| SCHEMBL5512060 | 0.77 | MAOB (0.63) | MAOBMAOAPTPN2PTPN1PTPRB | |
| SCHEMBL6442885 | 0.77 | MAOB (0.56) | MAOBMAOAAR | |
| SCHEMBL29442871 | 0.74 | NOS3 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0321385-B1 | Substituted thienoimidazole derivatives, process for their preparation, pharmaceutical compositions containing them and their use as gastric secretion inhibitors | HOECHST AG (DE) | 1994-08-17 | — | — | EP | disclosed |
| US-5114955-A | Derivatives with pyridine as gastrointestinal disorders and antisecretory agents | HOECHST AKETIENGESELLSCHAFT (DE) | 1992-05-19 | — | — | US | disclosed |
| EP-0321385-A2 | Substituted thienoimidazole derivatives, process for their preparation, pharmaceutical compositions containing them and their use as gastric secretion inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-06-21 | — | — | EP | disclosed |