Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5116198 | 0.87 | TSHR (0.46) | TSHRALDH1A1L3MBTL1MAPK1TDP1 | |
| SCHEMBL16682367 | 0.84 | LMNA (0.56) | TSHRALDH1A1L3MBTL1TDP1CYP3A4 | |
| SCHEMBL27512049 | 0.84 | CNR2 (0.55) | TSHRMAPK1LMNAHSD17B10NPC1 | |
| SCHEMBL9278775 | 0.83 | ALDH1A1 (0.64) | TSHRALDH1A1L3MBTL1MAPK1LMNA | |
| SCHEMBL29253290 | 0.81 | ALDH1A1 (0.49) | TSHRALDH1A1L3MBTL1MAPK1TDP1 | |
| SCHEMBL27457770 | 0.80 | LMNA (0.47) | TSHRALDH1A1MAPK1LMNAHSD17B10 | |
| SCHEMBL27343331 | 0.80 | CCR6 (0.56) | TSHRALDH1A1L3MBTL1MAPK1TDP1 | |
| SCHEMBL5696663 | 0.79 | CNR2 (0.60) | ALDH1A1L3MBTL1LMNAHSD17B10POLB | |
| SCHEMBL28271583 | 0.79 | CCR6 (0.58) | TSHRALDH1A1L3MBTL1MAPK1TDP1 | |
| SCHEMBL8551970 | 0.79 | LTB4R2 (0.55) | TSHRALDH1A1L3MBTL1MAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371183-A | Reacting diamine or polyamine with carbon dioxide in solvent in presence of sterically hindered amidine or guanidine to form salt, reacting with hydrocarbyl dihalide or polyhalide in polar aprotic solvent, polymerizing product | MONSANTO COMPANY (US) | 1994-12-06 | — | — | US | disclosed |
| US-5349048-A | Reaction of carbon dioxide with alcohol to form salt in solvent and reacting with hydrocarbyl halide | MONSANTO COMPANY (US) | 1994-09-20 | — | — | US | disclosed |
| US-5344934-A | Reaction of carbon dioxide and amine in aprotic solvents | MONSANTO COMPANY (US) | 1994-09-06 | — | — | US | disclosed |
| US-5260473-A | Reaction of alcohol and carbon dioxide in aprotic solvent and strong amidine or guanidine base | MONSANTO COMPANY (US) | 1993-11-09 | — | — | US | disclosed |
| US-5223638-A | Reacting primary or secondary amine with carbon dioxide in presence of strong amidine or guanidine base to form ammonium carbamate salt, reacting in polar aprotic solvent with primary or secondary hydrocarbyl halide | MONSANTO COMPANY (US) | 1993-06-29 | — | — | US | disclosed |