⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1371349 | 0.94 | — | — | |
| SCHEMBL8522382 | 0.92 | SHBG (0.39) | — | |
| Methylamine SCHEMBL27951566 | 0.90 | EPHX1 (0.32) | — | |
| SCHEMBL882385 | 0.88 | — | — | |
| Bromide SCHEMBL29487599 | 0.86 | — | — | |
| Sulfuric Acid SCHEMBL15389382 | 0.82 | EPHX1 (0.34) | — | |
| Phosphoric Acid SCHEMBL15389186 | 0.82 | MMP2 (0.42) | — | |
| SCHEMBL28773707 | 0.80 | JAK2 (0.32) | — | |
| SCHEMBL2759860 | 0.79 | TSHR (0.32) | — | |
| SCHEMBL11704037 | 0.77 | TSHR (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116096764-A | Functionalized polymers | 赢创运营有限公司 | 2023-05-09 | — | — | CN | claimed |
| CN-111356710-B | Functionalized polymers | 赢创运营有限公司 | 2022-04-26 | — | — | CN | claimed |
| CN-111356710-A | Functionalized polymers | 赢创运营有限公司 | 2020-06-30 | — | — | CN | claimed |
| CN-117285547-A | Macrocyclic compounds as modulators of CFTR, pharmaceutical compositions thereof, their use and methods of preparation | 弗特克斯药品有限公司 | 2023-12-26 | — | — | CN | disclosed |
| CN-112004817-B | Macrocyclic compounds as modulators of CFTR, pharmaceutical compositions thereof, their use and methods of preparation | 弗特克斯药品有限公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-116096764-A | Functionalized polymers | 赢创运营有限公司 | 2023-05-09 | — | — | CN | disclosed |
| EP-3802535-B1 | KRAS G12C INHIBITORS AND METHODS OF USING THE SAME | AMGEN INC (US) | 2022-12-14 | — | — | EP | disclosed |
| CN-111356710-B | Functionalized polymers | 赢创运营有限公司 | 2022-04-26 | — | — | CN | disclosed |
| EP-3802535-A1 | KRAS G12C INHIBITORS AND METHODS OF USING THE SAME | Amgen Inc. (US) | 2021-04-14 | — | — | EP | disclosed |
| CN-112004817-A | Macrocyclic compounds as modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions thereof, their use in the treatment of cystic fibrosis, and processes for their preparation | 弗特克斯药品有限公司 | 2020-11-27 | — | — | CN | disclosed |
| CN-111356710-A | Functionalized polymers | 赢创运营有限公司 | 2020-06-30 | — | — | CN | disclosed |
| CN-101160289-A | Pyridazine derivatives and their use as therapeutic agents | XENON PHARMACEUTICALS INC (CA) | 2008-04-09 | — | — | CN | disclosed |
| US-7335658-B2 | Pyridazine derivatives and their use as therapeutic agents | XENON PHARMACEUTICALS INC. (CA) | 2008-02-26 | — | — | US | disclosed |
| EP-1851205-A2 | PYRIDAZINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2007-11-07 | — | — | EP | disclosed |
| CN-1829698-A | Pyridazine derivatives and their use as therapeutic agents | XENON PHARMACEUTICALS INC (CA) | 2006-09-06 | — | — | CN | disclosed |
| WO-2006086447-A2 | PYRIDAZINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2006-08-17 | — | — | WO | disclosed |
| EP-1648874-A2 | PIPERAZINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2006-04-26 | — | — | EP | disclosed |
| US-20060009459-A1 | Pyridazine derivatives and their use as therapeutic agents | XENON PHARMACEUTICALS INC. (CA) | 2006-01-12 | — | — | US | disclosed |
| US-20050065143-A1 | Pyridazine derivatives and their use as therapeutic agents | XENON PHARMACEUTICALS INC. (CA) | 2005-03-24 | — | — | US | disclosed |
| WO-2005011655-A2 | PYRIDAZINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2005-02-10 | — | — | WO | disclosed |