Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 5/20 | 0.41 |
| ▸ | NOS2 | P35228 | 4/20 | 0.41 |
| ▸ | NOS3 | P29474 | 3/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5542429 | 0.79 | NOS1 (0.46) | NOS1NOS2NOS3BLMCYP1A2 | |
| SCHEMBL5542425 | 0.78 | NOS1 (0.41) | NOS1NOS2NOS3BLMCYP1A2 | |
| SCHEMBL522732 | 0.78 | NOS1 (0.44) | NOS1NOS2NOS3BLMCYP1A2 | |
| SCHEMBL9369604 | 0.78 | OGT (0.37) | NOS1NOS2NOS3BLMCYP1A2 | |
| SCHEMBL4416973 | 0.73 | PSMB8 (0.61) | NOS1NOS2NOS3BLMCYP1A2 | |
| SCHEMBL1250234 | 0.73 | PSMB8 (0.61) | NOS1NOS2NOS3BLMCYP1A2 | |
| SCHEMBL31139539 | 0.70 | NOS1 (0.49) | NOS1NOS2NOS3BLMCYP1A2 | |
| SCHEMBL8253228 | 0.70 | NOS1 (0.49) | NOS1NOS2NOS3BLMCYP1A2 | |
| SCHEMBL11151440 | 0.69 | KMO (0.55) | NOS1NOS2NOS3BLMCYP1A2 | |
| SCHEMBL11041800 | 0.69 | TYMS (0.44) | NOS1NOS2CYP1A2TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0385664-B1 | Antiinflammatory benzoxazolones | PFIZER (US) | 1994-01-12 | — | — | EP | disclosed |
| US-5086062-A | Inhibitors of lipoxygenase and-or cyclooxygenase enzymes | PFIZER INC. (US) | 1992-02-04 | — | — | US | disclosed |
| EP-0385664-A2 | Antiinflammatory benzoxazolones | PFIZER INC. (US) | 1990-09-05 | — | — | EP | disclosed |
| EP-0185618-A2 | Isoindolines, process for their manufacture and their use | CIBA-GEIGY AG (CH) | 1986-06-25 | — | — | EP | disclosed |