Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA7 | P43166 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28166126 | 0.87 | KDM4E (0.46) | KDM4EALDH1A1TSHRALOX15HSD17B10 | |
| SCHEMBL6559833 | 0.85 | TSHR (0.46) | KDM4EALDH1A1TSHRCYP4F2CYP4A11 | |
| SCHEMBL29897883 | 0.85 | TSHR (0.46) | KDM4EALDH1A1TSHRCYP4F2CYP4A11 | |
| SCHEMBL25255731 | 0.85 | KDM4E (0.49) | KDM4EALDH1A1TSHRALOX15HSD17B10 | |
| SCHEMBL29501650 | 0.85 | KDM4E (0.49) | KDM4EALDH1A1TSHRALOX15HSD17B10 | |
| SCHEMBL612735 | 0.84 | KDM4E (0.51) | KDM4EALDH1A1TSHRALOX15HSD17B10 | |
| SCHEMBL8627488 | 0.83 | CYP4F2 (0.50) | KDM4EALDH1A1TSHRCYP4F2CYP4A11 | |
| SCHEMBL277286 | 0.83 | CYP2C9 (0.54) | KDM4EALDH1A1TSHRALOX15HSD17B10 | |
| SCHEMBL12458000 | 0.83 | CA12 (0.56) | KDM4EALDH1A1TSHRALOX15HSD17B10 | |
| SCHEMBL9370371 | 0.82 | GABRP (0.46) | KDM4EALDH1A1TSHRALOX15MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220518-B1 | PREPARATION OF SUBSTITUTED AND DISUBSTITUTED PYRIDINE-2,3-DICARBOXYLATE ESTERS | AMERICAN CYANAMID COMPANY (US) | 1991-02-06 | — | — | EP | claimed |
| US-4723011-A | ALPHA-HALO-BETA-KETOESTERS, ALPHA, BETA UNSATURATED KETONE OR ALDEHYDE, AMMONIUM SALT | AMERICAN CYANAMID COMPANY (US) | 1988-02-02 | — | — | US | claimed |
| EP-0220518-A2 | Preparation of substituted and disubstituted pyridine-2,3-dicarboxylate esters | AMERICAN CYANAMID COMPANY (US) | 1987-05-06 | — | — | EP | claimed |
| EP-0388620-B1 | Process for the preparation of o-carboxypyridyl- and o-carboxyquinolylimidazolinones | AMERICAN CYANAMID CO (US) | 1994-11-02 | — | — | EP | disclosed |
| EP-0220518-B1 | PREPARATION OF SUBSTITUTED AND DISUBSTITUTED PYRIDINE-2,3-DICARBOXYLATE ESTERS | AMERICAN CYANAMID COMPANY (US) | 1991-02-06 | — | — | EP | disclosed |
| EP-0388620-A1 | Process for the preparation of o-carboxypyridyl- and o-carboxyquinolylimidazolinones | AMERICAN CYANAMID COMPANY (US) | 1990-09-26 | — | — | EP | disclosed |
| US-4925944-A | CONDENSATION AND CYCLIZATION IN AROMATIC SOLVENT AND SULFUR; ONE STEP; HERBICIDES | AMERICAN CYANAMID COMPANY (US) | 1990-05-15 | — | — | US | disclosed |
| US-4723011-A | ALPHA-HALO-BETA-KETOESTERS, ALPHA, BETA UNSATURATED KETONE OR ALDEHYDE, AMMONIUM SALT | AMERICAN CYANAMID COMPANY (US) | 1988-02-02 | — | — | US | disclosed |
| EP-0220518-A2 | Preparation of substituted and disubstituted pyridine-2,3-dicarboxylate esters | AMERICAN CYANAMID COMPANY (US) | 1987-05-06 | — | — | EP | disclosed |