SCHEMBL9370834

SCHEMBL9370834

CC(C(=O)O)N(C(=O)c1ccccc1)c1ccc(F)c(Cl)c1.CC(C(=O)O)N(C(=O)c1ccccc1)c1ccc(F)c(Cl)c1

nearest known ligand 0.48

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.46
RAB9A P51151 2/20 0.46
MDM4 O15151 2/20 0.43
MDM2 Q00987 2/20 0.43
MLYCD O95822 1/20 0.41
ALDH1A1 P00352 1/20 0.40
TRPM8 Q7Z2W7 1/20 0.40
PDK1 Q15118 3/20 0.40
HDAC8 Q9BY41 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
HTR2C P28335 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29438205 1.00 NPC1 (0.46) NPC1RAB9AMDM4MDM2MLYCD
SCHEMBL4454349 1.00 NPC1 (0.46) NPC1RAB9AMDM4MDM2MLYCD
SCHEMBL6013579 1.00 NPC1 (0.46) NPC1RAB9AMDM4MDM2MLYCD
SCHEMBL29695353 1.00 NPC1 (0.46) NPC1RAB9AMDM4MDM2MLYCD
SCHEMBL62782 1.00 NPC1 (0.46) NPC1RAB9AMDM4MDM2MLYCD
SCHEMBL29438203 1.00 NPC1 (0.46) NPC1RAB9AMDM4MDM2MLYCD
SCHEMBL4894601 1.00 NPC1 (0.46) NPC1RAB9AMDM4MDM2MLYCD
SCHEMBL126595 1.00 NPC1 (0.46) NPC1RAB9AMDM4MDM2MLYCD
SCHEMBL8541737 0.92 MEN1 (0.48) NPC1RAB9AMDM4MDM2TRPM8
SCHEMBL8674776 0.91 NPC1 (0.41) NPC1RAB9AMDM4MDM2MLYCD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0593433-A1 HERBICIDAL OXABICYCLO ETHERS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1994-04-27 EP disclosed
EP-0575503-A1 HERBICIDAL PYRIDINE SULFONAMIDE E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-12-29 EP disclosed
EP-0548264-A1 HERBICIDAL SUBSTITUTED BICYCLIC TRIAZOLES. DU PONT (US) 1993-06-30 EP disclosed
EP-0523067-A1 CROP-SELECTIVE HERBICIDAL SULFONAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-01-20 EP disclosed
WO-1992015576-A1 HERBICIDAL PYRIDINE SULFONAMIDE E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-09-17 WO disclosed
WO-1992004827-A1 HERBICIDAL SUBSTITUTED BICYCLIC TRIAZOLES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-04-02 WO disclosed
EP-0463054-A1 SELECTIVE OXABICYCLOALKANES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-01-02 EP disclosed
EP-0457802-A1 HERBICIDAL OXABICYCLONONANE ETHERS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-11-27 EP disclosed
WO-1991015478-A1 CROP-SELECTIVE HERBICIDAL SULFONAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-10-17 WO disclosed
WO-1991010653-A1 HERBICIDAL PYRIMIDINES AND TRIAZINES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-07-25 WO disclosed
WO-1991010668-A1 HERBICIDAL SULFONYLUREAS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-07-25 WO disclosed
WO-1991003464-A1 HERBICIDAL OXABICYCLO ETHERS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-03-21 WO disclosed
WO-1990012012-A1 SUBSTITUTED PHENYLTRIAZOLOPYRIMIDINE HERBICIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1990-10-18 WO disclosed
WO-1990010634-A1 SELECTIVE OXABICYCLOALKANES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1990-09-20 WO disclosed
WO-1990009383-A1 HERBICIDAL OXABICYCLONONANE ETHERS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1990-08-23 WO disclosed