Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 16/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9378183 | 0.85 | RIPK1 (0.66) | RIPK1ALDH1A1 | |
| SCHEMBL23162681 | 0.82 | ALDH1A1 (0.55) | RIPK1ALDH1A1 | |
| SCHEMBL9377931 | 0.81 | CYP3A4 (0.44) | RIPK1ALDH1A1MAOAMAOB | |
| SCHEMBL9370156 | 0.80 | RIPK1 (0.70) | RIPK1 | |
| SCHEMBL24351038 | 0.80 | RIPK1 (0.70) | RIPK1 | |
| SCHEMBL23161321 | 0.80 | RIPK1 (0.62) | RIPK1ALDH1A1 | |
| SCHEMBL27276665 | 0.79 | RIPK1 (0.71) | RIPK1 | |
| SCHEMBL23161335 | 0.78 | RIPK1 (0.59) | RIPK1ALDH1A1GAA | |
| SCHEMBL22037891 | 0.78 | RIPK1 (0.59) | RIPK1ALDH1A1 | |
| SCHEMBL18248336 | 0.78 | RIPK1 (0.75) | RIPK1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322691-B1 | Process for producing 1-acyl-2-pyrazoline derivatives | MITSUI TOATSU CHEMICALS (JP) | 1994-06-15 | — | — | EP | claimed |
| EP-0295695-B1 | Pyrazoline derivatives and agents for treating cerebrovascular diseases containing the same as active ingredient | MITSUI TOATSU CHEMICALS (JP) | 1994-06-08 | — | — | EP | claimed |
| US-4895947-A | Process for producing 1-acyl-2-pyrazoline derivative | MITSUI TOATSU CHEMICALS, INC. (JP) | 1990-01-23 | — | — | US | claimed |
| EP-0322691-A1 | Process for producing 1-acyl-2-pyrazoline derivatives | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1989-07-05 | — | — | EP | claimed |
| EP-0322691-B1 | Process for producing 1-acyl-2-pyrazoline derivatives | MITSUI TOATSU CHEMICALS (JP) | 1994-06-15 | — | — | EP | disclosed |
| EP-0295695-B1 | Pyrazoline derivatives and agents for treating cerebrovascular diseases containing the same as active ingredient | MITSUI TOATSU CHEMICALS (JP) | 1994-06-08 | — | — | EP | disclosed |
| CN-1015177-B | Method for producing 1-acyl-2-pyrazoline derivative | MITSUI TOATSU CHEMICALS (JP) | 1991-12-25 | — | — | CN | disclosed |
| CN-1014245-B | PREPN. OF PYRAZOLINE DERIVATIVES | MITSUI TOATSU CHEMICALS (JP) | 1991-10-09 | — | — | CN | disclosed |
| US-4990529-A | Nervous system disorder | MITSUI TOATSU CHEMICALS (JP) | 1991-02-05 | — | — | US | disclosed |
| US-4895947-A | Process for producing 1-acyl-2-pyrazoline derivative | MITSUI TOATSU CHEMICALS, INC. (JP) | 1990-01-23 | — | — | US | disclosed |
| CN-1033994-A | Produce the method for 1-acyl-2-pyrazoline derivative | MITSUI TOATSU CHEMICALS (JP) | 1989-07-19 | — | — | CN | disclosed |
| EP-0322691-A1 | Process for producing 1-acyl-2-pyrazoline derivatives | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1989-07-05 | — | — | EP | disclosed |
| US-4839376-A | Pyrazoline derivatives for treating cerebrovascular diseases | MITSUI TOATSU CHEMICALS, INC. (JP) | 1989-06-13 | — | — | US | disclosed |
| CN-88103735-A | It is the medicine of active ingredient treatment cerebrovascular disease that new pyrazoline derivative reaches with this compound | — | 1988-12-28 | — | — | CN | disclosed |
| EP-0295695-A2 | Pyrazoline derivatives and agents for treating cerebrovascular diseases containing the same as active ingredient | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1988-12-21 | — | — | EP | disclosed |