Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.59 |
| ▸ | CNR2 | P34972 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | FAAH | O00519 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | PPARG | P37231 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NCOA2 | Q15596 | 2/20 | 0.49 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.49 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.49 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9375272 | 0.89 | LMNA (0.60) | LMNAROCK1ROCK2CNR2NPC1 | |
| SCHEMBL9370393 | 0.89 | ROCK1 (0.61) | LMNAROCK1ROCK2CNR2NPC1 | |
| SCHEMBL9374540 | 0.88 | LMNA (0.61) | LMNAROCK1ROCK2CNR2FAAH | |
| SCHEMBL9376878 | 0.88 | LMNA (0.79) | LMNAROCK1ROCK2CNR2NPC1 | |
| SCHEMBL9370967 | 0.88 | ABL1 (0.62) | LMNAROCK1ROCK2CNR2NPC1 | |
| SCHEMBL9370971 | 0.88 | LMNA (0.61) | LMNAROCK1ROCK2CNR2NPC1 | |
| SCHEMBL9371263 | 0.87 | NPC1 (0.68) | LMNAROCK1ROCK2CNR2NPC1 | |
| SCHEMBL9371260 | 0.86 | HDAC3 (0.56) | LMNAROCK1ROCK2CNR2NPC1 | |
| SCHEMBL9370411 | 0.84 | ACHE (0.67) | LMNAROCK1ROCK2NPC1KDM4E | |
| SCHEMBL9370685 | 0.84 | GSTO1 (0.61) | LMNAROCK1ROCK2CNR2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0589985-A1 | 2-AMINO-4-ARYL-THIAZOLES WITH ANTIASTHMATIC AND ANTI-INFLAMMATORY ACTIVITIES ON THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1994-04-06 | — | — | EP | disclosed |
| WO-1993000342-A1 | 2-AMINO-4-ARYL-THIAZOLES WITH ANTIASTHMATIC AND ANTI-INFLAMMATORY ACTIVITIES ON THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1993-01-07 | — | — | WO | disclosed |
| EP-0519449-A1 | 2-Amino-4-aryl thiazoles with antiasthmatic and antiinflammatory activities on the respiratory tract | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-12-23 | — | — | EP | disclosed |