Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 9/20 | 0.43 |
| ▸ | TNKS | O95271 | 8/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 8/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | METAP2 | P50579 | 2/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | COMT | P21964 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7766975 | 0.80 | CYP1A2 (0.49) | CYP1A2ACHEPARP1TNKSTNKS2 | |
| SCHEMBL27842045 | 0.72 | TNKS (0.48) | PARP1TNKSTNKS2KDM4EADRA1A | |
| SCHEMBL17867403 | 0.67 | CYP1A2 (0.47) | CYP1A2ACHEPARP1TNKSTNKS2 | |
| SCHEMBL11193112 | 0.66 | ACHE (0.50) | CYP1A2ACHEPARP1TNKSTNKS2 | |
| SCHEMBL30528247 | 0.66 | KDM4E (0.44) | CYP1A2ACHEKDM4ETSHRMAPT | |
| SCHEMBL7721773 | 0.66 | HPGD (0.52) | CYP1A2PARP1KDM4ECYP2C9TSHR | |
| SCHEMBL15058512 | 0.66 | KDM4E (0.44) | CYP1A2ACHEKDM4ETSHRMAPT | |
| SCHEMBL20584754 | 0.64 | CCR1 (0.57) | KDM4ECYP2D6TSHRMAPTMETAP2 | |
| SCHEMBL7691626 | 0.64 | PARP1 (0.43) | CYP1A2ACHEPARP1TNKSTNKS2 | |
| SCHEMBL1003091 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0431991-B1 | 1,8-Benzonaphthyridine derivatives, their preparation and compositions containing them | BELLON LABOR SA ROGER (FR) | 1994-01-12 | — | — | EP | disclosed |
| EP-0379413-B1 | 1,8-Benzonaphthyridine derivatives, their production and compositions containing them | BELLON LABOR SA ROGER (FR) | 1993-12-22 | — | — | EP | disclosed |
| EP-0379414-B1 | 1,8-Benzonaphthyridine derivatives and their preparation | BELLON LABOR SA ROGER (FR) | 1993-12-22 | — | — | EP | disclosed |
| EP-0379412-B1 | 1,8-Benzonaphthyridine derivatives, their preparation and compositions containing them | BELLON LABOR SA ROGER (FR) | 1993-12-01 | — | — | EP | disclosed |
| EP-0431991-A1 | 1,8-Benzonaphthyridine derivatives, their preparation and compositions containing them | Société anonyme dite: LABORATOIRE ROGER BELLON (FR) | 1991-06-12 | — | — | EP | disclosed |
| EP-0379414-A1 | 1,8-Benzonaphthyridine derivatives and their preparation | Société anonyme dite: LABORATOIRE ROGER BELLON (FR) | 1990-07-25 | — | — | EP | disclosed |
| EP-0379412-A1 | 1,8-Benzonaphthyridine derivatives, their preparation and compositions containing them | Société anonyme dite: LABORATOIRE ROGER BELLON (FR) | 1990-07-25 | — | — | EP | disclosed |
| EP-0379413-A1 | 1,8-Benzonaphthyridine derivatives, their production and compositions containing them | Société anonyme dite: LABORATOIRE ROGER BELLON (FR) | 1990-07-25 | — | — | EP | disclosed |