Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 5/20 | 0.48 |
| ▸ | TNKS2 | Q9H2K2 | 5/20 | 0.48 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | JUND | P17535 | 1/20 | 0.42 |
| ▸ | FOSB | P53539 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7763515 | 0.82 | NQO2 (0.49) | TNKSTNKS2PARP2KDM4EALDH1A1 | |
| SCHEMBL24008917 | 0.75 | KDM4E (0.55) | TNKSTNKS2PARP2KDM4EALDH1A1 | |
| SCHEMBL1564635 | 0.73 | KDM4E (0.65) | TNKSTNKS2PARP2KDM4EALDH1A1 | |
| SCHEMBL27276202 | 0.72 | CA12 (0.50) | TNKSTNKS2PARP2KDM4EALDH1A1 | |
| SCHEMBL9370981 | 0.72 | CYP1A2 (0.44) | TNKSTNKS2KDM4EALDH1A1PARP1 | |
| SCHEMBL27664199 | 0.71 | KDM4E (0.38) | TNKSTNKS2PARP2KDM4EALDH1A1 | |
| SCHEMBL11195641 | 0.70 | NQO2 (0.50) | TNKSTNKS2PARP2KDM4EALDH1A1 | |
| SCHEMBL7692125 | 0.69 | KDM4E (0.59) | TNKSTNKS2PARP2KDM4EALDH1A1 | |
| SCHEMBL26766431 | 0.69 | CRHR1 (0.58) | TNKSTNKS2KDM4EALDH1A1HPGD | |
| SCHEMBL3946174 | 0.69 | TNKS (0.45) | TNKSTNKS2PARP2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102198133-B | Application of 8-difluoro methoxy fluoroquinolone and composition thereof to tuberculosis treatment | INST MEDICINAL BIOTECHNOLOGY | 2012-11-21 | — | — | CN | disclosed |
| CN-102198133-B | Application of 8-difluoro methoxy fluoroquinolone and composition thereof to tuberculosis treatment | INST MEDICINAL BIOTECHNOLOGY | 2012-11-21 | — | — | CN | disclosed |
| CN-102198133-A | Application of 8-difluoro methoxy fluoroquinolone and composition thereof to tuberculosis treatment | INST MED BIOTECHNOLOGY CAMS | 2011-09-28 | — | — | CN | disclosed |
| CN-102198133-A | Application of 8-difluoro methoxy fluoroquinolone and composition thereof to tuberculosis treatment | INST MED BIOTECHNOLOGY CAMS | 2011-09-28 | — | — | CN | disclosed |