SCHEMBL9371027

SCHEMBL9371027

CCOC(=O)NC(C)c1ccccc1

nearest known ligand 0.59

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.58
KMT2A Q03164 1/20 0.58
ACACB O00763 1/20 0.56
POLB P06746 3/20 0.53
KDM4E B2RXH2 1/20 0.52
ALDH1A1 P00352 1/20 0.52
HSD17B10 Q99714 1/20 0.51
GAA P10253 1/20 0.51
CTDSP1 Q9GZU7 1/20 0.51
MAPT P10636 1/20 0.51
MMP8 P22894 1/20 0.51
ATM Q13315 1/20 0.51
CTSK P43235 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18356975 0.85 MEN1 (0.57) MEN1KMT2APOLBKDM4EALDH1A1
SCHEMBL12986617 0.85 MEN1 (0.53) MEN1KMT2APOLBKDM4EALDH1A1
SCHEMBL12986619 0.85 MEN1 (0.53) MEN1KMT2APOLBKDM4EALDH1A1
SCHEMBL18210961 0.85 MEN1 (0.57) MEN1KMT2APOLBKDM4EALDH1A1
SCHEMBL962468 0.84 SMN1; SMN2 (0.63) KMT2APOLBKDM4EHSD17B10GAA
SCHEMBL13506014 0.84 LMNA (0.60) KMT2AGAAMAPTMMP8ATM
SCHEMBL9317172 0.84 POLB (0.58) MEN1KMT2AACACBPOLBALDH1A1
Carbenzide SCHEMBL2107475 0.83 GAA (0.57) MEN1KMT2APOLBKDM4EALDH1A1
SCHEMBL21469067 0.83 ATM (0.68) MEN1KMT2APOLBALDH1A1ATM
SCHEMBL8530402 0.83 ATM (0.68) MEN1KMT2APOLBALDH1A1ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114555570-A Oral complement factor D inhibitors 拜奥克里斯特制药公司 2022-05-27 CN disclosed
CN-104918942-A Pyrimidone derivatives and their use for treating, ameliorating or preventing viral diseases SAVIRA PHARMACEUTICALS GMBH 2015-09-16 CN disclosed
EP-0383316-B1 Process for the separation of enantiomers of benzopyran derivative MERCK PATENT GMBH (DE) 1994-02-02 EP disclosed
US-4952696-A Process for resolving the enantiomers of a benzopyran derivative MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) 1990-08-28 US disclosed
EP-0383316-A2 Process for the separation of enantiomers of benzopyran derivative MERCK PATENT GmbH (DE) 1990-08-22 EP disclosed