Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | HK1 | P19367 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL407439 | 0.78 | NPC1 (0.70) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL20042575 | 0.77 | NPC1 (0.48) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL2216919 | 0.76 | NPC1 (0.47) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL2217338 | 0.74 | NPC1 (0.55) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL3456349 | 0.74 | NPC1 (0.55) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL15894024 | 0.73 | NPC1 (0.44) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL9688137 | 0.72 | NPC1 (0.57) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL1893352 | 0.72 | ALDH1A1 (0.46) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6469101 | 0.70 | NPC1 (0.72) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL22605729 | 0.69 | MEN1 (0.37) | ALDH1A1MEN1KMT2AGAACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0315115-B1 | 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives, process for producing them and use thereof | MOCHIDA PHARM CO LTD (JP) | 1994-06-15 | — | — | EP | disclosed |
| US-5077410-A | Hypotensive agents, antiedemic agents and diuretics | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-31 | — | — | US | disclosed |
| EP-0243982-B1 | 1-ACYL-2,3-DIHYDRO-4(1H)-QUINOLINONE-4-OXIME DERIVATIVE, PROCESS FOR THE PRODUCTION THEREOF, PHARMACEUTICAL COMPOSITION AND INTERMEDIATES | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1991-04-17 | — | — | EP | disclosed |
| US-4968680-A | HYPOTENSIVE, ANTIEDEMIC, DIURETIC | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1990-11-06 | — | — | US | disclosed |
| US-4839368-A | DIURETICS, HYPOTENSIVE AGENTS, ANTIEDEMIC AGENTS | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1989-06-13 | — | — | US | disclosed |
| EP-0315115-A2 | 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives, process for producing them and use thereof | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1989-05-10 | — | — | EP | disclosed |
| WO-1987006580-A1 | 1-ACYL-2,3-DIHYDRO-4(1H)-QUINOLINONE-4-OXIME DERIVATIVES | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1987-11-05 | — | — | WO | disclosed |
| EP-0243982-A1 | 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivative, process for the production thereof, pharmaceutical composition and intermediates | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1987-11-04 | — | — | EP | disclosed |