Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 8/20 | 0.48 |
| ▸ | THRA | P10827 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9443972 | 0.85 | NPC1 (0.50) | KDM4EALOX5MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9374496 | 0.82 | SLC6A5 (0.48) | KDM4EALOX5LMNAMEN1KMT2A | |
| SCHEMBL9374202 | 0.79 | ALOX5 (0.73) | ALOX5 | |
| SCHEMBL9380104 | 0.76 | ALOX5 (0.58) | ALOX5MAPT | |
| SCHEMBL9473677 | 0.75 | ALOX5 (0.66) | KDM4EALOX5GLRA1 | |
| SCHEMBL9373618 | 0.74 | ALOX5 (0.57) | ALOX5MEN1KMT2A | |
| SCHEMBL1457712 | 0.73 | MEN1 (0.63) | KDM4ETHRATHRBLMNAMEN1 | |
| SCHEMBL3238114 | 0.73 | SMN1; SMN2 (0.48) | KDM4ETHRATHRBLMNAMEN1 | |
| SCHEMBL9373237 | 0.72 | ALOX5 (0.64) | ALOX5 | |
| SCHEMBL8405763 | 0.72 | LMNA (0.50) | KDM4ETHRATHRBLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588785-A1 | UREA BASED LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1994-03-30 | — | — | EP | disclosed |
| EP-0588785-A4 | UREA BASED LIPOXYGENASE INHIBITING COMPOUNDS. | ABBOTT LAB (US) | 1991-12-30 | — | — | EP | disclosed |
| WO-1990012008-A1 | UREA BASED LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1990-10-18 | — | — | WO | disclosed |