Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 18/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | LOX | P28300 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9488982 | 0.88 | ALOX5 (0.65) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL9374954 | 0.79 | ALOX5 (1.00) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL9379247 | 0.76 | ALOX5 (0.51) | ALOX5PTGESLMNALTA4HGAA | |
| SCHEMBL9475492 | 0.76 | ALOX5 (0.50) | ALOX5CYP1A2GAAALOX15 | |
| SCHEMBL9377433 | 0.75 | ALOX5 (0.69) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL9373722 | 0.72 | ALOX5 (0.60) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL9488975 | 0.69 | ALOX5 (0.56) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL4281496 | 0.67 | ALOX5 (0.54) | ALOX5CYP1A2LMNAALOX15 | |
| SCHEMBL5247753 | 0.66 | HTR1A (0.42) | ALOX5LMNA | |
| SCHEMBL9474991 | 0.66 | ALOX5 (0.71) | ALOX5CYP1A2PTGESLMNALTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588785-A1 | UREA BASED LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1994-03-30 | — | — | EP | disclosed |
| EP-0588785-A4 | UREA BASED LIPOXYGENASE INHIBITING COMPOUNDS. | ABBOTT LAB (US) | 1991-12-30 | — | — | EP | disclosed |
| WO-1990012008-A1 | UREA BASED LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1990-10-18 | — | — | WO | disclosed |