Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 2/20 | 0.40 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.38 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9376526 | 0.81 | MAOB (0.45) | ALDH1A1MMP1MMP12TP53LMNA | |
| SCHEMBL9376612 | 0.81 | PGR (0.43) | PGRKDM4EALDH1A1SMN1; SMN2USP2 | |
| SCHEMBL4848196 | 0.81 | CA2 (0.47) | PGRBMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL9375554 | 0.79 | IDO1 (0.38) | TP53LMNA | |
| SCHEMBL9773848 | 0.76 | POLB (0.57) | PGRBMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL24112743 | 0.72 | PGR (0.46) | PGRBMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL13091038 | 0.72 | PGR (0.46) | PGRBMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL24112740 | 0.70 | PGR (0.45) | PGRBMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL2239581 | 0.70 | PGR (0.45) | PGRBMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL24112918 | 0.70 | PGR (0.60) | PGRBMPR1BBMPR1ATGFBR1ACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0344634-B1 | Bicyclic carboxamides, process for their preparation and medicaments containing them | BOEHRINGER MANNHEIM GMBH (DE) | 1994-03-30 | — | — | EP | disclosed |
| EP-0344634-A1 | Bicyclic carboxamides, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1989-12-06 | — | — | EP | disclosed |