Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | HTR1A | P08908 | 6/20 | 0.42 |
| ▸ | HTR7 | P34969 | 4/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9595257 | 0.81 | HTR2A (0.61) | ADRA1DADRA1BHTR2AHTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL9595572 | 0.80 | HTR2A (0.60) | ADRA1DADRA1BHTR2AHTR1AHTR7 | |
| SCHEMBL8595848 | 0.79 | HTR1A (0.60) | ADRA1DADRA1BHTR2AHTR1AHTR7 | |
| SCHEMBL8598448 | 0.77 | HTR1A (0.57) | ADRA1DADRA1BHTR2AHTR1AHTR7 | |
| SCHEMBL9376347 | 0.77 | DRD2 (0.71) | HTR1AHTR7DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL9380070 | 0.76 | DRD2 (0.69) | HTR1AHTR7DRD2DRD3 | |
| SCHEMBL9376666 | 0.73 | DRD3 (0.62) | HTR1AHTR7DRD2DRD3 | |
| SCHEMBL4430426 | 0.73 | HTR1A (0.64) | ADRA1DADRA1BHTR2AHTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL9287779 | 0.72 | HTR1A (0.63) | ADRA1DADRA1BHTR2AHTR1AHTR7 | |
| SCHEMBL8597120 | 0.72 | HTR1A (0.51) | NPC1MITFPKMRAB9AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625978-A1 | PIPERAZINE AND PIPERIDINE DERIVATIVES, AND THEIR USE AS ANTIPSYCHOTICS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-11-30 | — | — | EP | claimed |
| EP-0625978-A1 | PIPERAZINE AND PIPERIDINE DERIVATIVES, AND THEIR USE AS ANTIPSYCHOTICS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-11-30 | — | — | EP | disclosed |