Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.74 |
| ▸ | MAPT | P10636 | 5/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.69 |
| ▸ | HPGD | P15428 | 2/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | PTGES | O14684 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9269100 | 0.88 | KDM4E (0.64) | KDM4EMAPTLMNAHPGDSMN1; SMN2 | |
| SCHEMBL9665121 | 0.81 | KDM4E (0.77) | KDM4EMAPTLMNAHPGDSMN1; SMN2 | |
| SCHEMBL7815045 | 0.81 | KDM4E (0.97) | KDM4EMAPTLMNAHPGDSMN1; SMN2 | |
| SCHEMBL9425215 | 0.80 | KDM4E (0.56) | KDM4EMAPTLMNAHPGDSMN1; SMN2 | |
| SCHEMBL9375339 | 0.79 | SOAT2 (0.57) | — | |
| SCHEMBL9370118 | 0.79 | SOAT2 (0.58) | — | |
| SCHEMBL9370785 | 0.79 | SOAT2 (0.58) | — | |
| SCHEMBL5466784 | 0.78 | KDM4E (0.62) | KDM4EMAPTLMNAHPGDSMN1; SMN2 | |
| SCHEMBL9370520 | 0.78 | KDM4E (0.55) | KDM4EMAPTLMNAHPGDSMN1; SMN2 | |
| SCHEMBL18106939 | 0.76 | KDM4E (0.64) | KDM4ELMNAHPGDALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5318984-A | Anticholesterol agents which inhibit acetyl coenzyme A transferase | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-06-07 | — | — | US | disclosed |
| EP-0372445-B1 | Imidazoles for the treatment of atherosclerosis | DU PONT MERCK PHARMA (US) | 1994-03-09 | — | — | EP | disclosed |
| US-5166214-A | Enzyme inhibitors for anticholesterol agents, enzyme inhibitor and cardiovascular disorders | DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-11-24 | — | — | US | disclosed |
| WO-1991018885-A1 | IMIDAZOLES FOR THE TREATMENT OF ATHEROSCLEROSIS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-12-12 | — | — | WO | disclosed |
| EP-0372445-A1 | Imidazoles for the treatment of atherosclerosis | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1990-06-13 | — | — | EP | disclosed |